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Details on Person Centrosomal abnormalities are frequently observed in cancers...
| Class:Id | Summation:374075 |
|---|---|
| _displayName | Centrosomal abnormalities are frequently observed in cancers... |
| _timestamp | 2009-04-25 19:44:44 |
| created | [InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19 |
| modified | [InstanceEdit:374080] Saxena, A, 2008-07-25 17:03:15 [InstanceEdit:418661] D'Eustachio, P, 2009-04-25 19:44:44 |
| text | Centrosomal abnormalities are frequently observed in cancers and in cells with defective DNA repair. Chk1 controlled centrosome duplication is a general response to DNA damage in tumor cells, especially in cells arrested at the G2-M phase of the cell cycle or in an extended S-phase under conditions of hydroxyurea-induced replication stress. Chicken DT40 cells expressing kinase-dead (D130A) or phosphorylation site(S345A) Chk1 mutants, or cells in which Chk1 levels were knocked down, did not show centrosome overduplication, indicating an essential role of Chk1 catalytic activity in this process. The centrosomal localization of human Chk1 also indicates a potential role at the centrosome. It is still unclear whether the actual role for Chk1 signaling is to cause a cell-cycle delay, or if Chk1 directly affects centromere amplification upon DNA damage. A role for Cdc25-mediated regulation of Cdk2 (cyclin dependent kinase2) acting downstream of Chk1 has also been implicated. |
| (summation) | [Pathway:217106] Chk1-controlled and DNA-damage induced centrosome duplication [Gallus gallus] |
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No pathways have been reviewed or authored by Centrosomal abnormalities are frequently observed in cancers... (374075)
