Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person The ability of cells to tolerate DNA damage, even at the cos...
| Class:Id | Summation:374074 |
|---|---|
| _displayName | The ability of cells to tolerate DNA damage, even at the cos... |
| _timestamp | 2009-04-24 22:34:13 |
| created | [InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19 |
| modified | [InstanceEdit:374080] Saxena, A, 2008-07-25 17:03:15 [InstanceEdit:418633] D'Eustachio, P, 2009-04-24 22:33:38 |
| text | The ability of cells to tolerate DNA damage, even at the cost of decreased genomic stability, is as biologically important as their ability to repair such damage. Such tolerance to unexcised lesions encountered during replication is attributed to DNA damage bypass pathways that utilize novel Y family polymerases to allow resumption of the movement of DNA replication forks that stall after encountering damage. Translesion synthesis (TLS) utilizes the error-prone DNA polymerase (Pol) zeta, Pol eta and Pol kappa, which lack 3' to 5' exonuclease activities and synthesize DNA with low fidelity and weak processivity. The combination of these activities allows the TLS Pols to bypass the damaged bases and thereby restore movement of a stalled replication fork. Rad6/Rad18 mediated mono-ubiquitination of PCNA plays an important, albeit incompletely worked out, role in recruiting such polymerases at the damaged sites (Edmunds et al. 2008). |
| (summation) | [Pathway:353488] DNA damage bypass [Gallus gallus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by The ability of cells to tolerate DNA damage, even at the cos... (374074)
