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Details on Person Damage to single nucleotides in a DNA duplex is common, ofte...
| Class:Id | Summation:374073 |
|---|---|
| _displayName | Damage to single nucleotides in a DNA duplex is common, ofte... |
| _timestamp | 2009-04-24 15:54:05 |
| created | [InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19 |
| modified | [InstanceEdit:374080] Saxena, A, 2008-07-25 17:03:15 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 |
| text | Damage to single nucleotides in a DNA duplex is common, often due to the action of endogenous oxidizing agents or environmental stresses. Base excision repair is a two-step process to repair such damage. First, a DNA glycosylase recognizes a specific modified base in a damaged strand of a DNA duplex and removes it by catalyzing cleavage of the glycosylic bond, leaving an abasic site without disruption of the phosphate-sugar DNA backbone of the damaged strand. Then, these apurinic or apyrimidinic (AP) sites are resolved by cleavage of the backbone of the damaged strand and removal of deoxyribose, insertion of a nucleotide residue or residues complementry to those in the undamaged strand, and ligation. Base excision repair may occur by either a single-nucleotide replacement pathway or a multiple-nucleotide patch replacement pathway, depending on the structure of the terminal sugar phosphate residue (Lindahl and Wood 1999). |
| (summation) | [Pathway:353357] Base Excision Repair [Gallus gallus] |
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No pathways have been reviewed or authored by Damage to single nucleotides in a DNA duplex is common, ofte... (374073)
