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Details on Person UniProt:Q9YHY9 OTC
| Class:Id | ReferenceGeneProduct:374030 |
|---|---|
| _chainChangeLog | transit peptide:1-32 added on Fri February 6 2015;chain:33-354 added on Fri February 6 2015 |
| _displayName | UniProt:Q9YHY9 OTC |
| _timestamp | 2025-02-21 19:30:39 |
| chain | transit peptide:1-32 chain:33-354 |
| checksum | 20447180BAD9D4ED |
| comment | FUNCTION Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:7332529). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (Probable).CATALYTIC ACTIVITY carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)ACTIVITY REGULATION Inhibition by ornithine increases at higher pH.BIOPHYSICOCHEMICAL PROPERTIES With an increase in pH, a decrease in KM values for ornithine and an increase in the extent of inhibition by ornithine are observed.PATHWAY Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1.SUBUNIT Homotrimer.SUBCELLULAR LOCATION Expressed in kidney, brain, heart, liver, pancreas, gizzard, small intestine and breast muscle. More abundant in mitochondrion-rich organs (heart, liver and brain) than in other organs. Activity is only detected in the kidney.DEVELOPMENTAL STAGE Activity detectable in embryos by day 14. Increases until 7 days post-hatching, then decreases again.INDUCTION By diet of egg yolk in animals which have a high level of OTC activity due to presence of OCB gene.PTM Cleavage of the precursor form to the active form occurs only in the kidney.MISCELLANEOUS Ornithine transcarbamylase activity varies within and between different breeds of chicken.SIMILARITY Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. |
| created | [InstanceEdit:374028] D'Eustachio, P, 2008-07-24 22:35:47 |
| description | recommendedName: fullName evidence="10"Ornithine transcarbamylase, mitochondrial shortName evidence="8"OTCase ecNumber evidence="6"2.1.3.3 alternativeName: Ornithine carbamoyltransferase, mitochondrial |
| geneName | OTC |
| identifier | Q9YHY9 |
| isSequenceChanged | FALSE |
| keyword | Amino-acid biosynthesis Arginine biosynthesis Mitochondrion Reference proteome Transferase Transit peptide Urea cycle |
| modified | [InstanceEdit:374048] D'Eustachio, P, 2008-07-24 22:36:40 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | OTC |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | OTC_CHICK |
| sequenceLength | 354 |
| species | [Species:49591] Gallus gallus |
| (referenceEntity) | [EntityWithAccessionedSequence:374046] OTC [mitochondrial matrix] [Gallus gallus] |
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No pathways have been reviewed or authored by UniProt:Q9YHY9 OTC (374030)
