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Details on Person Ankyrins link voltage-gated sodium and pottasium channels to spectrin and L1

Class:Id	Reaction:373737
_displayName	Ankyrins link voltage-gated sodium and pottasium channels to spectrin and L1
_doRelease	TRUE
_timestamp	2010-12-02 14:41:56
authored	[InstanceEdit:374671] Garapati, P V, 2008-07-30 10:22:58
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:373740] Garapati, P V, 2008-07-16 14:41:28
edited	[InstanceEdit:374671] Garapati, P V, 2008-07-30 10:22:58
input	[EntityWithAccessionedSequence:373632] Neurofascin [plasma membrane] [Rattus norvegicus] [DefinedSet:443634] Sodium channel beta subunit [plasma membrane] [Rattus norvegicus]
literatureReference	[LiteratureReference:373492] Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain [LiteratureReference:443755] Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates [LiteratureReference:443759] Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments [LiteratureReference:421387] Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues [LiteratureReference:443756] A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon [LiteratureReference:443766] Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates
modified	[InstanceEdit:443771] Garapati, P V, 2009-10-12 [InstanceEdit:446625] Garapati, P V, 2009-11-16 [InstanceEdit:447049] Garapati, P V, 2009-11-19 [InstanceEdit:447051] Garapati, P V, 2009-11-19 [InstanceEdit:448355] Garapati, P V, 2009-11-24 [InstanceEdit:513003] Garapati, P V, 2010-02-16 [InstanceEdit:532606] Garapati, P V, 2010-03-01 [InstanceEdit:750980] Garapati, P V, 2010-05-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ankyrins link voltage-gated sodium and pottasium channels to spectrin and L1
output	[Complex:373692] Neuropfascin:Na channel beta 1 complex [plasma membrane] [Rattus norvegicus]
releaseDate	2010-06-15
reviewed	[InstanceEdit:513001] Maness, PF, 2010-02-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48895] Rattus norvegicus
stableIdentifier	[StableIdentifier:1105934] R-RNO-373737.2
summation	[Summation:373605] Ankyrins link both L1 and ion channel proteins, coupling the...
(inferredFrom)	[Reaction:373739] Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 [Homo sapiens]
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