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Details on Person DCC heterodimerizes with UNC-5:Netrin-1

Class:Id	Reaction:373713
_displayName	DCC heterodimerizes with UNC-5:Netrin-1
_doRelease	TRUE
_timestamp	2024-11-13 19:26:19
authored	[InstanceEdit:373757] Garapati, P V, 2008-07-16 14:42:16
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:373710] Garapati, P V, 2008-07-16 14:40:16
edited	[InstanceEdit:374705] Garapati, P V, 2008-07-30 10:24:23
input	[Complex:373660] NTN1:UNC5 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:197560] DCC [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:9928280] Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin [LiteratureReference:9928281] The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue
modified	[InstanceEdit:418877] Garapati, P V, 2009-04-27 09:28:58 [InstanceEdit:420399] Garapati, P V, 2009-05-11 14:21:13 [InstanceEdit:421692] Garapati, P V, 2009-05-19 13:46:02 [InstanceEdit:421713] Garapati, P V, 2009-05-19 19:47:47 [InstanceEdit:422008] Garapati, P V, 2009-05-25 19:36:41 [InstanceEdit:425943] Garapati, P V, 2009-06-09 [InstanceEdit:446620] Garapati, P V, 2009-11-15 [InstanceEdit:448356] Garapati, P V, 2009-11-24 [InstanceEdit:513007] Garapati, P V, 2010-02-16 [InstanceEdit:532573] Garapati, P V, 2010-03-01 [InstanceEdit:624279] Garapati, P V, 2010-04-26 [InstanceEdit:763358] Garapati, P V, 2010-05-20 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9928273] Garapati, Phani Vijay, 2024-11-13
name	DCC heterodimerizes with UNC-5:Netrin-1
output	[Complex:373654] DCC:NTN1:UNC5 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:373751] UNC-5 binds Netrin-1 [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:513006] Cooper, HM, 2010-02-16
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105118] R-HSA-373713.3
summation	[Summation:373615] UNC-5 uses DCC as a co-receptor and binds to the DCC P1 doma...
(hasEvent)	[Pathway:418886] Netrin mediated repulsion signals [Homo sapiens]
(precedingEvent)	[Reaction:418859] Phosphorylation of Unc5C [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9928459] Update Tracker - [Reaction:373713] DCC heterodimerizes with UNC-5:Netrin-1 - v91:[removeLiteratureReference]
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No pathways have been reviewed or authored by DCC heterodimerizes with UNC-5:Netrin-1 (373713)