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Details on Person DCC exerts its pro-apoptotic effect when netrin ligand is ab...
| Class:Id | Summation:373587 |
|---|---|
| _displayName | DCC exerts its pro-apoptotic effect when netrin ligand is ab... |
| _timestamp | 2012-10-24 10:00:08 |
| created | [InstanceEdit:373580] Garapati, P V, 2008-07-16 14:31:31 |
| literatureReference | [LiteratureReference:373540] Role of the dependence receptor DCC in colorectal cancer pathogenesis [LiteratureReference:2534128] The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis |
| modified | [InstanceEdit:421643] Garapati, P V, 2009-05-19 13:35:48 [InstanceEdit:421712] Garapati, P V, 2009-05-19 19:27:03 [InstanceEdit:2534138] Garapati, P V, 2012-10-24 |
| text | DCC exerts its pro-apoptotic effect when netrin ligand is absent. When unbound to its ligand, DCC is cleaved roughly in the middle of its intracellular domain (aspartic acid residue 1290) by caspase-3 (Mehlen et al. 1998). The cleavage releases DCC's inhibitory C-terminal domain and exposes the addiction/dependence domain (ADD), which is sufficient for cell death induction. |
| (summation) | [Reaction:373705] Caspase cleavage of DCC [Homo sapiens] |
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No pathways have been reviewed or authored by DCC exerts its pro-apoptotic effect when netrin ligand is ab... (373587)
