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Details on Person Rac1 activated in response to the integrin signaling stimula...
| Class:Id | Summation:372992 |
|---|---|
| _displayName | Rac1 activated in response to the integrin signaling stimula... |
| _timestamp | 2008-07-11 13:03:40 |
| created | [InstanceEdit:372995] Garapati, P V, 2008-07-11 13:03:29 |
| literatureReference | [LiteratureReference:372997] Regulation of WASP/WAVE proteins: making a long story short |
| text | Rac1 activated in response to the integrin signaling stimulates the activation of Arp2/3 complex. Activation of Rac is relayed to Arp2/3 via Wiskott-Aldrich syndrome proteins (WASPs). Five WASP family proteins exist in mammals- WASP, N-WASP and three WASP family verprolin homologous (WAVE) proteins. WAVE proteins play a major role in Rac-induced actin dynamics. WAVE-1 exists as a pentameric complex, which includes p53 inducible messanger RNA (PIR121), Nck-associated protein (Nap1), Abl-interactor (Abi) and HSPC300. On stimulation this pentameric complex is recruited to the Rac1. |
| (summation) | [Reaction:372696] Recruitment of WAVE/PIR121/Nap1/Abi complex to Rac1 [Homo sapiens] |
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No pathways have been reviewed or authored by Rac1 activated in response to the integrin signaling stimula... (372992)
