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Details on Person UniProt:Q5ZME2 MDH1
Class:Id
ReferenceGeneProduct:372857
_chainChangeLog
chain:1-334 added on Fri February 6 2015
_displayName
UniProt:Q5ZME2 MDH1
_timestamp
2025-02-21 20:01:02
chain
chain:1-334
checksum
2AD5D831DC812332
comment
FUNCTION Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS).CATALYTIC ACTIVITY (S)-malate + NAD(+) = oxaloacetate + NADH + H(+)CATALYTIC ACTIVITY (S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)SUBUNIT Homodimer.SUBCELLULAR LOCATION Belongs to the LDH/MDH superfamily. MDH type 2 family.
