Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q9YHT1 SDHA
| Class:Id | ReferenceGeneProduct:372829 |
|---|---|
| _chainChangeLog | transit peptide:1-44 added on Sat February 7 2015;chain:45-665 added on Sat February 7 2015 |
| _displayName | UniProt:Q9YHT1 SDHA |
| _timestamp | 2025-02-21 19:53:52 |
| chain | transit peptide:1-44 chain:45-665 |
| checksum | 9476AA19A7A3AE84 |
| comment | FUNCTION Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable) (PubMed:16371358). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity).CATALYTIC ACTIVITY a ubiquinone + succinate = a ubiquinol + fumarateCATALYTIC ACTIVITY (R)-malate + a quinone = enol-oxaloacetate + a quinolCATALYTIC ACTIVITY (S)-malate + a quinone = enol-oxaloacetate + a quinolCOFACTOR Enol-oxaloacetate inhibits the succinate dehydrogenase activity.PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.SUBUNIT Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.SUBCELLULAR LOCATION Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. |
| created | [InstanceEdit:372825] D'Eustachio, P, 2008-07-03 22:18:15 |
| description | recommendedName: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial ecNumber evidence="6"1.3.5.1 alternativeName: Flavoprotein subunit of complex II shortName: Fp alternativeName: Malate dehydrogenase [quinone] flavoprotein subunit ecNumber evidence="1"1.1.5.- |
| geneName | SDHA |
| identifier | Q9YHT1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Electron transport FAD Flavoprotein Membrane Mitochondrion Mitochondrion inner membrane Oxidoreductase Reference proteome Transit peptide Transport Tricarboxylic acid cycle |
| modified | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8869714] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SDHA |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SDHA_CHICK |
| sequenceLength | 665 |
| species | [Species:49591] Gallus gallus |
| (referenceEntity) | [EntityWithAccessionedSequence:373128] SDHA [mitochondrial inner membrane] [Gallus gallus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9YHT1 SDHA (372829)
