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Details on Person As integrins do not have an intrinsic catalytic activity, th...
| Class:Id | Summation:372633 |
|---|---|
| _displayName | As integrins do not have an intrinsic catalytic activity, th... |
| _timestamp | 2019-01-14 20:18:17 |
| created | [InstanceEdit:372634] Garapati, P V, 2008-06-27 10:06:55 |
| literatureReference | [LiteratureReference:354120] Biochemical signals and biological responses elicited by the focal adhesion kinase [LiteratureReference:354182] Integrin-regulated FAK-Src signaling in normal and cancer cells [LiteratureReference:377572] Integrins and Src: dynamic duo of adhesion signaling |
| modified | [InstanceEdit:373152] Garapati, P V, 2008-07-14 13:52:16 [InstanceEdit:377577] Garapati, P V, 2008-09-15 17:58:41 [InstanceEdit:939908] Jupe, S, 2010-09-02 [InstanceEdit:9634734] Rothfels, Karen, 2019-01-14 |
| text | As integrins do not have an intrinsic catalytic activity, the signals initiated by the ECM-integrin interactions are transduced into cells through the integrin bound protein-tyrosine kinases. PTK2 (protein-tyrosine kinase 2, also known as Focal adhesion kinase 1; FADK1, FAK) is one of the protein tyrosine kinases that plays a prominent role in integrin signaling. PTK2 has been implicated in controlling cell motility and transmitting a cell survival signal from ECM. PTK2 is recruited to sites of integrin clustering by directly binding to integrin associated c-Src. |
| (summation) | [Reaction:354066] Translocation of PTK2 to Focal complexes [Homo sapiens] |
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No pathways have been reviewed or authored by As integrins do not have an intrinsic catalytic activity, th... (372633)
