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Details on Person Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr...

Class:IdSummation:372629
_displayNamePhosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr...
_timestamp2019-01-14 20:18:37
created[InstanceEdit:372630] Garapati, P V, 2008-06-27 10:04:33
literatureReference[LiteratureReference:354156] Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
[LiteratureReference:375028] Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix
modified[InstanceEdit:373164] Garapati, P V, 2008-07-14 14:12:43
[InstanceEdit:392042] Garapati, P V, 2009-02-26 17:40:31
[InstanceEdit:420749] D'Eustachio, P, 2009-05-13 15:09:14
[InstanceEdit:939908] Jupe, S, 2010-09-02
[InstanceEdit:9634742] Rothfels, Karen, 2019-01-14
textPhosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway.
(summation)[Reaction:354087] Recruitment of GRB2 to p-PTK2 [Homo sapiens]
[Reaction:392051] Recruitment of Grb2 to pFAK:NCAM1 [Homo sapiens]
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