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Details on Person Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr...
| Class:Id | Summation:372629 |
| _displayName | Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr... |
| _timestamp | 2019-01-14 20:18:37 |
| created | [InstanceEdit:372630] Garapati, P V, 2008-06-27 10:04:33 |
| literatureReference | [LiteratureReference:354156] Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase [LiteratureReference:375028] Binding properties of the neural cell adhesion molecule to different components of the extracellular matrix |
| modified | [InstanceEdit:373164] Garapati, P V, 2008-07-14 14:12:43 [InstanceEdit:392042] Garapati, P V, 2009-02-26 17:40:31 [InstanceEdit:420749] D'Eustachio, P, 2009-05-13 15:09:14 [InstanceEdit:939908] Jupe, S, 2010-09-02 [InstanceEdit:9634742] Rothfels, Karen, 2019-01-14 |
| text | Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway. |
| (summation) | [Reaction:354087] Recruitment of GRB2 to p-PTK2 [Homo sapiens] [Reaction:392051] Recruitment of Grb2 to pFAK:NCAM1 [Homo sapiens] |
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No pathways have been reviewed or authored by Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr... (372629)