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Details on Person AcCho is hydrolyzed to Cho and acetate by ACHE

Class:IdReaction:372519
_displayNameAcCho is hydrolyzed to Cho and acetate by ACHE
_doReleaseTRUE
_timestamp2021-04-16 19:14:34
authored[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity[CatalystActivity:1524052] acetylcholinesterase activity of Cholinesterase [plasma membrane]
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:372526] Mahajan, SS, 2008-06-26 18:29:42
edited[InstanceEdit:380916] Mahajan, SS, 2008-11-18 00:03:09
goBiologicalProcess[GO_BiologicalProcess:19389] acetylcholine catabolic process
input[SimpleEntity:372533] AcCho [extracellular region]
[SimpleEntity:109276] H2O [extracellular region]
literatureReference[LiteratureReference:372541] Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity
[LiteratureReference:1482734] The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant
[LiteratureReference:1482716] Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
modified[InstanceEdit:374942] Mahajan, SS, 2008-08-05 20:37:09
[InstanceEdit:377665] Gillespie, ME, 2008-09-15 21:36:00
[InstanceEdit:386900] Mahajan, SS, 2008-11-27 13:02:33
[InstanceEdit:387387] Gillespie, ME, 2008-12-02 04:32:31
[InstanceEdit:387494] Gopinathrao, G, 2008-12-02 20:59:59
[InstanceEdit:1602349] Williams, MG, 2011-09-14
[InstanceEdit:2230933] D'Eustachio, P, 2012-05-05
[InstanceEdit:8946993] Shorser, Solomon, 2016-11-07
[InstanceEdit:9634837] Jassal, Bijay, 2019-01-16
[InstanceEdit:9696622] Jassal, Bijay, 2020-07-23
[InstanceEdit:9727432] D'Eustachio, Peter, 2021-04-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameAcCho is hydrolyzed to Cho and acetate by ACHE
Acetylcholine clearance from synaptic cleft
output[SimpleEntity:264638] Cho [extracellular region]
[SimpleEntity:1524044] acetate [extracellular region]
regulatedBy[NegativeRegulation:9634836] Negative regulation by 'ACHE:ACHEIs [plasma membrane]'
releaseDate2008-09-30
reviewed[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:377940] R-HSA-372519.6
summation[Summation:373212] Acetylcholinesterase (ACHE) oligomers (comprising monomers, ...
(hasEvent)[Pathway:112311] Neurotransmitter clearance [Homo sapiens]
[Pathway:1483191] Synthesis of PC [Homo sapiens]
(precedingEvent)[Reaction:444433] Cho transports from the extracellular space to the cytosol [Homo sapiens]
[Reaction:1483001] Cho transports from the extracellular space to the cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778352] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v68:[addRegulator]
[_UpdateTracker:9788548] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v41:[modifyText]
[_UpdateTracker:9788972] Update Tracker - [Reaction:372519] AcCho is hydrolyzed to Cho and acetate by ACHE - v39:[addInput, addLiteratureReference, add_removeCatalystActivity, add_removeOutput, modifyText]
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