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Details on Person Acetylcholine synaptic vesicle docking and priming

Class:Id	Reaction:372505
_displayName	Acetylcholine synaptic vesicle docking and priming
_doRelease	TRUE
_timestamp	2020-03-13 17:28:08
authored	[InstanceEdit:210542] Mahajan, SS, 2008-01-14 16:01:52
catalystActivity	[CatalystActivity:373336] SNARE binding activity of Acetylcholine Loaded Synaptic Vesicle [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:372526] Mahajan, SS, 2008-06-26 18:29:42
edited	[InstanceEdit:447013] Gillespie, ME, 2009-11-19
input	[EntityWithAccessionedSequence:210514] STXBP1-1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2029017] SNAP25 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:210385] CPLX1 [cytosol] [Homo sapiens] [Complex:264786] Acetylcholine Loaded Synaptic Vesicle [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:449128] STX1A [plasma membrane] [Homo sapiens] [Complex:210374] RIMS1:UNC13B:BZRAP1:Alpha-liprin [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:210526] Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells [LiteratureReference:210443] Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles [LiteratureReference:349529] Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus [LiteratureReference:349544] Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation
modified	[InstanceEdit:374942] Mahajan, SS, 2008-08-05 20:37:09 [InstanceEdit:383392] Gillespie, ME, 2008-11-26 16:16:16 [InstanceEdit:447316] Mahajan, SS, 2009-11-21 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1172020] D'Eustachio, P, 2011-01-19 [InstanceEdit:2980881] Jassal, Bijay, 2013-01-14 [InstanceEdit:3004547] Jassal, Bijay, 2013-01-29 [InstanceEdit:3065963] Jupe, S, 2013-02-06 [InstanceEdit:5545440] Jupe, Steve, 2014-05-21 [InstanceEdit:5545441] Jupe, Steve, 2014-05-21 [InstanceEdit:8946993] Shorser, Solomon, 2016-11-07 [InstanceEdit:9678183] Gillespie, Marc E, 2020-03-13 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Acetylcholine synaptic vesicle docking and priming
output	[Complex:372534] Docked acetylcholine loaded Synaptic Vesicle [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:210444] L-Glutamate loading of synaptic vesicle [Homo sapiens] [Reaction:210404] SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ [Homo sapiens] [BlackBoxEvent:379324] Re-acidification of glutamate transport vesicle [Homo sapiens] [Reaction:70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] [Homo sapiens] [Reaction:70609] glutamine + H2O => glutamate + NH4+ (GLS) [Homo sapiens] [Reaction:264615] Loading of acetylcholine in synaptic vesicles [Homo sapiens] [Reaction:264622] Cho is acetylated to AcCho by CHAT [Homo sapiens] [BlackBoxEvent:349520] Re-acidification of acetylcholine transport vesicles [Homo sapiens]
releaseDate	2008-12-17
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49 [InstanceEdit:9674802] Wen, Hua, 2020-01-24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:387744] R-HSA-372505.4
summation	[Summation:374892] Docking and priming of acetylcholine loaded transport vesicl...
(hasEvent)	[Pathway:264642] Acetylcholine Neurotransmitter Release Cycle [Homo sapiens]
(precedingEvent)	[Reaction:372529] Release of acetylcholine at the synapse [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777300] Update Tracker - [Reaction:372505] Acetylcholine synaptic vesicle docking and priming - v72:[modifyText] [_UpdateTracker:9786515] Update Tracker - [Reaction:372505] Acetylcholine synaptic vesicle docking and priming - v49:[add_removeInput] [_UpdateTracker:9787546] Update Tracker - [Reaction:372505] Acetylcholine synaptic vesicle docking and priming - v44:[add_removeInput] [_UpdateTracker:9789977] Update Tracker - [Reaction:372505] Acetylcholine synaptic vesicle docking and priming - v36:[modifyText]
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