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Details on Person TP53 stimulates MDM2 transcription

Class:Id	BlackBoxEvent:3700992
_displayName	TP53 stimulates MDM2 transcription
_doRelease	TRUE
_timestamp	2016-02-19 18:22:51
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3700993] Orlic-Milacic, M, 2013-06-11
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:3700996] MDM2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3245948] The p53-mdm-2 autoregulatory feedback loop
modified	[InstanceEdit:6806013] Orlic-Milacic, Marija, 2015-10-21 [InstanceEdit:8856342] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8856588] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates MDM2 transcription
output	[EntityWithAccessionedSequence:69486] MDM2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:3700997] TP53 binds the MDM2 gene [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:3700995] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:MDM2 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9641864] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:MDM2 Gene [nucleoplasm]' The p53-mdm-2 autoregulatory feedback loop
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861443] R-HSA-3700992.4
summation	[Summation:6806011] Binding of TP53 (p53) to the p53 response element in the fir...
(hasEvent)	[Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(precedingEvent)	[Reaction:6795667] MDM2 translocates to the cytosol [Homo sapiens]
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No pathways have been reviewed or authored by TP53 stimulates MDM2 transcription (3700992)