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Details on Person TP53 family members bind the BAX promoter

Class:Id	Reaction:3700981
_displayName	TP53 family members bind the BAX promoter
_doRelease	TRUE
_timestamp	2016-02-19 18:21:20
authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:3700983] Orlic-Milacic, M, 2013-06-11
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
input	[EntityWithAccessionedSequence:3700977] BAX gene [nucleoplasm] [Homo sapiens] [Complex:6799788] (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2) [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3700985] Tumor suppressor p53 is a direct transcriptional activator of the human bax gene [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members
modified	[InstanceEdit:6799248] Orlic-Milacic, Marija, 2015-09-22 [InstanceEdit:6799795] Orlic-Milacic, Marija, 2015-09-25 [InstanceEdit:6799806] Orlic-Milacic, Marija, 2015-09-25 [InstanceEdit:6803268] Orlic-Milacic, Marija, 2015-10-05 [InstanceEdit:6809228] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809229] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6809233] Orlic-Milacic, Marija, 2015-11-09 [InstanceEdit:6810433] Orlic-Milacic, Marija, 2015-11-16 [InstanceEdit:6810437] Orlic-Milacic, Marija, 2015-11-17 [InstanceEdit:8856055] Orlic-Milacic, Marija, 2016-02-08 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 family members bind the BAX promoter
output	[Complex:3700978] (p-S15,S20-TP53,TP63,TP73):(PPP1R13B,TP53BP2):BAX Gene [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6799777] TP53 family members bind PPP1R13B or TP53BP2 [Homo sapiens] [Reaction:6799246] CHEK1 phosphorylates TP53 [Homo sapiens] [Reaction:69685] CHEK2 phosphorylates TP53 [Homo sapiens] [Reaction:6805285] PLK3 phosphorylates TP53 [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861204] R-HSA-3700981.2
summation	[Summation:6799794] TP53 (p53) binds the p53 response element in the promoter of...
(hasEvent)	[Pathway:6803204] TP53 Regulates Transcription of Genes Involved in Cytochrome C Release [Homo sapiens]
(normalReaction)	[FailedReaction:3701023] TP53 R175H does not bind BAX promoter [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:3700984] TP53 family members stimulate BAX transcription [Homo sapiens]
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No pathways have been reviewed or authored by TP53 family members bind the BAX promoter (3700981)