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Details on Person Missense mutations in the kinase domain (KD) of TGF-beta rec...
| Class:Id | Summation:3654163 |
|---|---|
| _displayName | Missense mutations in the kinase domain (KD) of TGF-beta rec... |
| _timestamp | 2013-05-30 20:39:27 |
| created | [InstanceEdit:3654167] Orlic-Milacic, M, 2013-05-30 |
| text | Missense mutations in the kinase domain (KD) of TGF-beta receptor II (TGFBR2) are found in ~20% of microsatellite stable (MSS) colon cancers and make affected tumors resistant to TGF-beta (TGFB1)-mediated growth inhibition (Grady et al. 1999). While both alleles of TGFBR2 are affected by inactivating mutations in MSS colorectal cancer (Grady et al. 1999), a study of MSS esophageal carcinoma indicates that TGFBR2 KD mutations may function in a dominant-negative way (Tanaka et al. 2000). KD mutations in TGFBR2 are rarely reported in microsatellite instable (MSI) colorectal cancer (Parsons et al. 1995, Takenoshita et al. 1997). |
| (summation) | [Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer [Homo sapiens] |
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No pathways have been reviewed or authored by Missense mutations in the kinase domain (KD) of TGF-beta rec... (3654163)
