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Details on Person TGFBR2 KD mutants do not phosphorylate TGFBR1

Class:Id	FailedReaction:3645780
_displayName	TGFBR2 KD mutants do not phosphorylate TGFBR1
_doRelease	TRUE
_timestamp	2018-11-29 16:12:03
authored	[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08 [InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08 [InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:3645784] Orlic-Milacic, M, 2013-05-30
disease	[Disease:1500689] cancer
edited	[InstanceEdit:4223999] Orlic-Milacic, M, 2013-08-08
entityFunctionalStatus	[EntityFunctionalStatus:3645781] loss_of_function of TGFB1:TGFBR2 KD Mutants:TGFBR1 [plasma membrane]
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:3645785] TGFB1:TGFBR2 KD Mutants:TGFBR1 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:3640895] Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers [LiteratureReference:3645769] A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma [LiteratureReference:3656279] Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase
modified	[InstanceEdit:3645788] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3654173] Orlic-Milacic, M, 2013-05-30 [InstanceEdit:3656281] Orlic-Milacic, M, 2013-05-31 [InstanceEdit:4224003] Orlic-Milacic, M, 2013-08-15 [InstanceEdit:4410468] Orlic-Milacic, M, 2013-08-23 [InstanceEdit:4542299] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:4542300] Orlic-Milacic, M, 2013-09-04 [InstanceEdit:9608149] Orlic-Milacic, Marija, 2018-05-10 [InstanceEdit:9630181] Orlic-Milacic, Marija, 2018-11-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TGFBR2 KD mutants do not phosphorylate TGFBR1
normalReaction	[Reaction:170843] TGFBR2 phosphorylates TGFBR1 [Homo sapiens]
releaseDate	2013-09-18
reviewed	[InstanceEdit:4224000] Meyer, Dominique, 2013-08-08 [InstanceEdit:4223997] Akhurst, Rosemary J, 2013-08-08
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:4545259] R-HSA-3645780.4
summation	[Summation:3654172] Phosphorylation of TGFBR1 by TGFBR2 kinase domain (KD) mutan...
(hasEvent)	[Pathway:3645790] TGFBR2 Kinase Domain Mutants in Cancer [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777869] Update Tracker - [FailedReaction:3645780] TGFBR2 KD mutants do not phosphorylate TGFBR1 - v68:[modifyText]
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No pathways have been reviewed or authored by TGFBR2 KD mutants do not phosphorylate TGFBR1 (3645780)