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Details on Person Ub-RibC-AXIN is degraded by the proteasome

Class:Id	BlackBoxEvent:3640874
_displayName	Ub-RibC-AXIN is degraded by the proteasome
_doRelease	TRUE
_timestamp	2014-11-20 02:30:02
authored	[InstanceEdit:3640727] Rothfels, K, 2013-05-29
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3640875] Rothfels, K, 2013-05-29
edited	[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input	[Complex:3640854] Ub-RibC-AXIN:TNKS:RNF146 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:3640792] RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling [LiteratureReference:3640796] Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling [LiteratureReference:3640803] Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
modified	[InstanceEdit:3774858] Rothfels, K, 2013-06-25 [InstanceEdit:4416357] Rothfels, K, 2013-08-25 [InstanceEdit:4518465] Rothfels, K, 2013-09-03 [InstanceEdit:4655175] Rothfels, K, 2013-10-02 [InstanceEdit:5097309] Rothfels, K, 2013-11-11 [InstanceEdit:5146732] Rothfels, K, 2013-11-18 [InstanceEdit:5251633] Rothfels, K, 2014-02-04 [InstanceEdit:5323614] Rothfels, K, 2014-02-15 [InstanceEdit:5576937] Rothfels, Karen, 2014-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Ub-RibC-AXIN is degraded by the proteasome
output	[EntityWithAccessionedSequence:3640827] RNF146 [cytosol] [Homo sapiens] [DefinedSet:3640826] TNKS1/2 [cytosol] [Homo sapiens] [DefinedSet:113595] Ub [cytosol] [Homo sapiens]
precedingEvent	[Reaction:3640861] RNF146 ubiquitinates ADP-ribosylated AXIN [Homo sapiens] [Reaction:3640844] RNF146 binds RibC-AXIN:TNKS complex [Homo sapiens]
releaseDate	2014-03-12
reviewed	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5323527] van Amerongen, R, 2014-02-14 [InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5644193] R-HSA-3640874.2
summation	[Summation:3640831] In the presence of the proteasome inhibitor MG132, polyubiqu...
(hasEvent)	[Pathway:4641257] Degradation of AXIN [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9965500] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965510] Futile Cycle: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965517] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965518] Futile Cycle: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965533] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965537] Futile Cycle: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965539] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965540] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome [NegativePrecedingEvent:9965545] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome
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