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Details on Person RNF146 ubiquitinates ADP-ribosylated AXIN

Class:IdReaction:3640861
_displayNameRNF146 ubiquitinates ADP-ribosylated AXIN
_doReleaseTRUE
_timestamp2025-08-29 19:55:29
authored[InstanceEdit:3632861] Rothfels, K, 2013-05-27
catalystActivity[CatalystActivity:3640855] ubiquitin protein ligase activity of RibC-AXIN:TNKS:RNF146 [cytosol]
compartment[Compartment:70101] cytosol
created[InstanceEdit:3640857] Rothfels, K, 2013-05-29
edited[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
input[DefinedSet:113595] Ub [cytosol] [Homo sapiens]
[Complex:3640845] RibC-AXIN:TNKS:RNF146 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:3640792] RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
[LiteratureReference:3640803] Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling
modified[InstanceEdit:3772517] Rothfels, K, 2013-06-25
[InstanceEdit:4416357] Rothfels, K, 2013-08-25
[InstanceEdit:4518454] Rothfels, K, 2013-09-03
[InstanceEdit:4655160] Rothfels, K, 2013-10-02
[InstanceEdit:5097288] Rothfels, K, 2013-11-11
[InstanceEdit:5146731] Rothfels, K, 2013-11-18
[InstanceEdit:5251613] Rothfels, K, 2014-02-04
[InstanceEdit:5323584] Rothfels, K, 2014-02-15
[InstanceEdit:5576921] Rothfels, Karen, 2014-05-27
[InstanceEdit:8981389] Rothfels, Karen, 2017-03-06
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9965547] Orlic-Milacic, Marija, 2025-08-29
nameRNF146 ubiquitinates ADP-ribosylated AXIN
negativePrecedingEvent[NegativePrecedingEvent:9965538] Futile Cycle: USP34 deubiquitinates AXIN1,AXIN2
[NegativePrecedingEvent:9965508] Abundant Molecules: USP8 deubiquitinates FZD to potentiate WNT signaling
[NegativePrecedingEvent:9965517] Abundant Molecules: Ub-RibC-AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965527] Abundant Molecules: Ubiquitinated AXIN is degraded by the proteasome
[NegativePrecedingEvent:9965526] Abundant Molecules: Ubiquitinated DVL is degraded by the proteasome
[NegativePrecedingEvent:9965523] Abundant Molecules: Ubiquitinated DVL1 is degraded by the proteasome
output[Complex:3640854] Ub-RibC-AXIN:TNKS:RNF146 [cytosol] [Homo sapiens]
precedingEvent
releaseDate2014-03-12
reviewed[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:5644489] R-HSA-3640861.4
summation[Summation:3640850] RNF146 has in vitro and in vivo ubiquitination activity agai...
(hasEvent)[Pathway:4641257] Degradation of AXIN [Homo sapiens]
(precedingEvent)[Reaction:3640872] USP34 deubiquitinates AXIN1,AXIN2 [Homo sapiens]
[BlackBoxEvent:3640874] Ub-RibC-AXIN is degraded by the proteasome [Homo sapiens]
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