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Details on Person Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

Class:IdLiteratureReference:3640789
_displayNameAxin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
_timestamp2018-07-12 19:37:33
author[Person:3640671] Ikeda, Satoshi
[Person:3640674] Kishida, Shosei
[Person:3238067] Yamamoto, Hideki
[Person:3640717] Murai, Hiroshi
[Person:3640677] Koyama, Shinya
[Person:4640987] Kikuchi, Akira
created[InstanceEdit:3640788] Rothfels, K, 2013-05-29
journalEMBO J.
modified[InstanceEdit:9613273] D'Eustachio, Peter, 2018-07-12
pages1371-84
pubMedIdentifier9482734
titleAxin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin
volume17
year1998
(literatureReference)[Reaction:209096] Murine Axin1 is dephosphorylated by PP2A leading to reduced binding affinity with beta-catenin [Mus musculus]
[BlackBoxEvent:3601585] PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex [Homo sapiens]
[Reaction:5229343] AXIN is phosphorylated in the destruction complex [Homo sapiens]
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