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Details on Person CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

Class:Id	Complex:3601581
_displayName	CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
_timestamp	2014-11-20 04:10:55
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:3601582] Rothfels, K, 2013-05-22
hasComponent	[EntityWithAccessionedSequence:448839] CTNNB1 [cytosol] [Homo sapiens] [Complex:3601577] p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:195263] CSNK1A1 [cytosol] [Homo sapiens] [Complex:196206] PP2A [cytosol] [Homo sapiens] [CandidateSet:196216] PP2A regulatory subunit B56 [cytosol] [Homo sapiens] [CandidateSet:165990] PP2A-subunit A [cytosol] [Homo sapiens] [CandidateSet:165977] PP2A-catalytic subunit C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:1504189] AMER1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2997551] GSK3B [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:206040] p-T481,S486,S493-AXIN1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5246690] K63polyUb-APC [cytosol] [Homo sapiens]
modified	[InstanceEdit:4658502] Rothfels, K, 2013-10-04 [InstanceEdit:5492221] Rothfels, Karen, 2014-05-20
name	CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex CTNNB1:destruction complex beta-catenin:destruction complex
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:5648398] R-HSA-3601581.1
(input)	[Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha [Homo sapiens]
(normalEntity)	[EntityFunctionalStatus:4827390] loss_of_function of CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol]
(output)	[Reaction:195304] Association of beta-catenin with the destruction complex [Homo sapiens]
(physicalEntity)	[CatalystActivity:1505509] protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
(replacementInstances)	[_Deleted:8944409] Deletion of instance: 195301
(updatedInstance)	[_UpdateTracker:9889725] Update Tracker - [Complex:3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] - v49:[modifyName, updateContainedComponent]
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No pathways have been reviewed or authored by CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (3601581)