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Details on Person UniProt:Q9JJH7 Trpm5
| Class:Id | ReferenceGeneProduct:357032 |
|---|---|
| _chainChangeLog | chain:1-1158 added on Fri February 6 2015 |
| _displayName | UniProt:Q9JJH7 Trpm5 |
| _timestamp | 2024-11-03 19:59:06 |
| chain | chain:1-1158 |
| checksum | F0A5237EC67867CE |
| comment | FUNCTION Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:12842017, PubMed:14657398, PubMed:17522321, PubMed:38538847). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:12842017). Activated directly by increase in intracellular Ca(2+), but is impermeable to it (PubMed:12842017). The activation mechanism of TRPM5 involves a multistep process. TRPM5 activation involves ligand binding (i.e., tastant molecule, glucose stimulation) to Gq/G-protein coupled receptors (GPCR) and leads to the breakdown of phosphatidylinositol bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause Ca(2+) release. Simultaneously with the intracellular Ca(2+) release, DAG activates the protein kinase C (PKC), which phosphorylates the TRPM5 channel. This phosphorylation combined with the bound Ca(2+), leads to a robust inward current allowing the entry of sodium ions (Na+) into the cell. This ion influx depolarizes the cell membrane, generating action potentials that propagate TRPM5 signals. Is a key player in sensing sweet, umami and bitter stimuli (Probable) (PubMed:16436689, PubMed:16935556). May also be involved in sensing semiochemicals (PubMed:17267604). Involved in insulin secretion by pancreatic beta cells (PubMed:20194741, PubMed:20393858).CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)ACTIVITY REGULATION Ca(2+)-activated cation channel (PubMed:12842017, PubMed:14657398, PubMed:17522321). Displays voltage dependence modulation (PubMed:12842017). Regulated by PI(4,5)P2 levels. PI(4,5)P 2 reverses the Ca(2+) -induced desensitization of channels (PubMed:14657398, PubMed:17522321). Inhibited by flufenamic acid with an IC(50) of 24.5 uM and spermine with an IC(50) of 37 uM (PubMed:15670874). Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials (PubMed:16355226). The channel is blocked by extracellular acidification (PubMed:15731110).SUBUNIT Homotetramer.SUBCELLULAR LOCATION Strongly expressed in liver, heart, testis, brain and kidney. Detected in fetal liver, kidney, spleen, brain, heart and lung, and in adult skin, eyes, spleen, stomach, small intestine, colon, lung, bladder, pancreas and thymus. Biallelically expressed at all stages and tissues examined. Also expressed in subsets of taste receptor cells of the tongue, in olfactory sensory neurons of the main olfactory epithelium and in the vomeronasal organ.DOMAIN Contains two Ca(2+)-binding sites that are allosterically coupled. The binding site in the intracellular domain modulates the voltage dependence and the accessibility of Ca(2+) in the transmembrane domain.PTM Multiple phosphorylation sites regulate the Gq/ TRPM5 modulation axis, with the Ser-129 playing a substantial role in this positive modulation.DISRUPTION PHENOTYPE Mice show diminished behavioral and nerve responses to bitter, sweet and umami tastes (PubMed:16436689). Glucose-induced insulin release from pancreatic islets isolated from Trpm5-deficient mice is significantly reduced, resulting in an impaired glucose tolerance in Trpm5-deficient mice (PubMed:20194741).SIMILARITY Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily. |
| created | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 |
| description | recommendedName: Transient receptor potential cation channel subfamily M member 5 alternativeName: Long transient receptor potential channel 5 shortName: LTrpC-5 shortName: LTrpC5 alternativeName: MLSN1- and TRP-related gene 1 protein |
| geneName | Trpm5 Ltrpc5 Mtr1 |
| identifier | Q9JJH7 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Calcium Cell membrane Coiled coil Ion channel Ion transport Ligand-gated ion channel Membrane Metal-binding Phosphoprotein Receptor Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel |
| modified | [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | Trpm5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TRPM5_MOUSE A3KN89 Q3TU14 Q7TPL4 Q99NF9 Q9EPM3 Q9EPM4 |
| sequenceLength | 1158 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:357033] UniProt:Q9JJH7-2 Trpm5 [Mus musculus] [ReferenceIsoform:357034] UniProt:Q9JJH7-3 Trpm5 [Mus musculus] [ReferenceIsoform:414528] UniProt:Q9JJH7-1 Trpm5 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9717430] Trpm5 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9JJH7 Trpm5 (357032)
