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Details on Person UniProt:Q9BUM1 G6PC3
| Class:Id | ReferenceGeneProduct:355266 |
|---|---|
| _chainChangeLog | chain:1-346 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BUM1 G6PC3 |
| _timestamp | 2024-11-03 20:01:00 |
| chain | chain:1-346 |
| checksum | 55C1F322E59C8439 |
| comment | FUNCTION Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function.CATALYTIC ACTIVITY D-glucose 6-phosphate + H2O = D-glucose + phosphateACTIVITY REGULATION Inhibited by vanadate.BIOPHYSICOCHEMICAL PROPERTIES 8 times less active compared to G6PC1 under the same experimental conditions.PATHWAY Carbohydrate biosynthesis; gluconeogenesis.SUBCELLULAR LOCATION Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart, brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung, small intestine and peripheral blood lymphocytes.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the glucose-6-phosphatase family.CAUTION According to PubMed:12370122, it has no hydrolytic activity. |
| created | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 |
| description | recommendedName: Glucose-6-phosphatase 3 shortName: G-6-Pase 3 shortName: G6Pase 3 ecNumber: 3.1.3.9 alternativeName: Glucose-6-phosphatase beta shortName: G6Pase-beta alternativeName: Ubiquitous glucose-6-phosphatase catalytic subunit-related protein |
| geneName | G6PC3 UGRP |
| identifier | Q9BUM1 |
| isSequenceChanged | FALSE |
| keyword | Disease variant Endoplasmic reticulum Gluconeogenesis Hydrolase Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | G6PC3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995991] ENSEMBL:ENSG00000141349 G6PC3 [Homo sapiens] |
| secondaryIdentifier | G6PC3_HUMAN Q8WU15 |
| sequenceLength | 346 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:981605] G6PC3 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:3276572] G6PC3 R253H [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:3276581] G6PC3 G260R [endoplasmic reticulum membrane] [Homo sapiens] |
| (referenceSequence) | [ReplacedResidue:3276563] glycine 260 replaced with L-arginine [ReplacedResidue:3276571] L-arginine 253 replaced with L-histidine |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BUM1 G6PC3 (355266)
