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Details on Person UniProt:A6ND01 IZUMO1R

Class:Id	ReferenceGeneProduct:355246
_chainChangeLog	signal peptide:1-19 added on Fri February 6 2015;chain:20-228 added on Fri February 6 2015;propeptide:229-250 added on Fri February 6 2015
_displayName	UniProt:A6ND01 IZUMO1R
_timestamp	2025-02-21 18:57:45
chain	signal peptide:1-19 chain:20-228 propeptide:229-250
checksum	CBF2FD967ABAF6E7
comment	FUNCTION Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:30517645). The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate.SUBUNIT Monomer (PubMed:27309808). Interacts with IZUMO1; the interaction is direct. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:24739963, PubMed:27309808, PubMed:27309818, PubMed:30517645). Interacts with FCRL3/MAIA; FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, thereby permitting species-specific gamete fusion (PubMed:36070373). Interacts with WDR54 (By similarity).INTERACTION GPI-anchored at the oolemma microvilli.ALTERNATIVE PRODUCTS Expressed in unfertilized oocytes (at protein level).PTM The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm.MISCELLANEOUS Gene prediction based on similarity to orthologs.SIMILARITY Belongs to the folate receptor family.
created	[InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12
description	recommendedName: fullName evidence="10"Sperm-egg fusion protein Juno alternativeName: Folate receptor 4 alternativeName: fullName evidence="2"Folate receptor delta shortName evidence="2"FR-delta alternativeName: fullName evidence="9"IZUMO1 receptor protein JUNO
geneName	IZUMO1R FOLR4 JUNO
identifier	A6ND01
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell membrane Cell projection Disulfide bond Fertilization Glycoprotein GPI-anchor Lipoprotein Membrane Proteomics identification Receptor Reference proteome Signal
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	IZUMO1R
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9000645] ENSEMBL:ENSG00000183560 IZUMO1R [Homo sapiens]
secondaryIdentifier	JUNO_HUMAN
sequenceLength	250
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8972445] UniProt:A6ND01-1 IZUMO1R [Homo sapiens] [ReferenceIsoform:8972446] UniProt:A6ND01-2 IZUMO1R [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:8940421] IZUMO1R [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8940746] GPI-IZUMO1R [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8941116] cleaved GPI-IZUMO1R [extracellular region] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:8940751] L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 228 [GroupModifiedResidue:8941117] L-serine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 228
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No pathways have been reviewed or authored by UniProt:A6ND01 IZUMO1R (355246)