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Details on Person UniProt:Q9NQ92 COPRS
| Class:Id | ReferenceGeneProduct:354852 |
|---|---|
| _chainChangeLog | chain:1-184 added on Sat February 7 2015 |
| _displayName | UniProt:Q9NQ92 COPRS |
| _timestamp | 2024-11-03 19:35:47 |
| chain | chain:1-184 |
| checksum | 38D3E94C34C48745 |
| comment | FUNCTION Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).SUBUNIT Interacts with PRMT5. Interacts with histone H4; specifically interacts with the N-terminus of histone H4 but not with histone H3. Interacts with CBFB (By similarity). Found in a complex with PRMT5, RUNX1 and CBFB (By similarity). |
| created | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 |
| description | recommendedName: Coordinator of PRMT5 and differentiation stimulator alternativeName: Cooperator of PRMT5 alternativeName: Protein TTP1 |
| geneName | COPRS C17orf79 COPR5 |
| identifier | Q9NQ92 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Chromatin regulator Direct protein sequencing Myogenesis Nucleus Phosphoprotein Proteomics identification Reference proteome Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | COPRS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8995917] ENSEMBL:ENSG00000172301 COPRS [Homo sapiens] |
| secondaryIdentifier | COPRS_HUMAN A6NP14 E1P656 Q96EF5 Q96P75 |
| sequenceLength | 184 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5212681] COPRS [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9NQ92 COPRS (354852)
