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Details on Person UniProt:Q8NAA4 ATG16L2
| Class:Id | ReferenceGeneProduct:354396 |
|---|---|
| _chainChangeLog | chain:1-619 added on Sat February 7 2015 |
| _displayName | UniProt:Q8NAA4 ATG16L2 |
| _timestamp | 2025-05-21 21:22:35 |
| chain | chain:1-619 |
| checksum | 7F2962AA3C6BB850 |
| comment | FUNCTION May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.SUBUNIT Homooligomer. Heterooligomer with ATG16L1. Interacts with ATG5. Self-oligomerizes to form a 800-kDa complex composed of ATG12-ATG5 and ATG16L2. Interacts with RAB33B.SUBCELLULAR LOCATION Also localizes to discrete punctae along the ciliary axoneme.ALTERNATIVE PRODUCTS Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies in mouse suggest that ATG16L2 is not essential for canonical autophagy.SIMILARITY Belongs to the WD repeat ATG16 family. |
| created | [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 |
| description | recommendedName: fullName evidence="6"Protein Atg16l2 alternativeName: APG16-like 2 alternativeName: Autophagy-related protein 16-2 alternativeName: WD repeat-containing protein 80 |
| geneName | ATG16L2 WDR80 |
| identifier | Q8NAA4 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Coiled coil Cytoplasm Protein transport Proteomics identification Reference proteome Repeat Transport WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | ATG16L2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987663] ENSEMBL:ENSG00000168010 ATG16L2 [Homo sapiens] |
| secondaryIdentifier | A16L2_HUMAN A5PL30 B2RPK5 Q658V4 Q6PID3 Q8NBG0 |
| sequenceLength | 619 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:354397] UniProt:Q8NAA4-2 ATG16L2 [Homo sapiens] [ReferenceIsoform:354398] UniProt:Q8NAA4-3 ATG16L2 [Homo sapiens] [ReferenceIsoform:411438] UniProt:Q8NAA4-1 ATG16L2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9936619] ATG16L2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q8NAA4 ATG16L2 (354396)
