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Details on Person Recruitment of GRB2 to p-PTK2

Class:IdReaction:354087
_displayNameRecruitment of GRB2 to p-PTK2
_doReleaseTRUE
_timestamp2019-01-14 20:18:47
authored[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:354078] Garapati, P V, 2008-06-16 17:02:05
edited[InstanceEdit:354193] Garapati, P V, 2008-06-16 17:13:06
input[Complex:354080] Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] [Homo sapiens]
literatureReference[LiteratureReference:354100] The structural basis of localization and signaling by the focal adhesion targeting domain
[LiteratureReference:354156] Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
[LiteratureReference:354148] Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events
modified[InstanceEdit:354203] Garapati, P V, 2008-06-16 17:32:15
[InstanceEdit:372630] Garapati, P V, 2008-06-27 10:04:33
[InstanceEdit:373162] Garapati, P V, 2008-07-14 14:09:25
[InstanceEdit:373930] Garapati, P V, 2008-07-18 08:43:11
[InstanceEdit:373945] Garapati, P V, 2008-07-22 08:39:18
[InstanceEdit:377699] Garapati, P V, 2008-09-16 06:34:17
[InstanceEdit:383278] Garapati, P V, 2008-11-24 15:57:15
[InstanceEdit:939908] Jupe, S, 2010-09-02
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9634746] Rothfels, Karen, 2019-01-14
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameRecruitment of GRB2 to p-PTK2
output[Complex:354113] GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-12-17
requiredInputComponent[EntityWithAccessionedSequence:354128] p-6Y-PTK2 [cytosol] [Homo sapiens]
reviewed[InstanceEdit:377695] Shattil, SJ, 2008-09-16 06:21:39
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:387586] R-HSA-354087.3
summation[Summation:372629] Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK cr...
(hasEvent)[Pathway:354194] GRB2:SOS provides linkage to MAPK signaling for Integrins [Homo sapiens]
(precedingEvent)[Reaction:354165] Interaction of SOS with GRB2 bound to FADK1 [Homo sapiens]
(updatedInstance)[_UpdateTracker:9778017] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v68:[modifyText]
[_UpdateTracker:9790277] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v34:[modifyText]
[_UpdateTracker:9791499] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v29:[modifyText]
[_UpdateTracker:9791574] Update Tracker - [Reaction:354087] Recruitment of GRB2 to p-PTK2 - v28:[modifyText]
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