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Details on Person Sos-1 bound to Grb2:FAK:Integrin complex promotes the exchan...

Class:Id	Summation:354058
_displayName	Sos-1 bound to Grb2:FAK:Integrin complex promotes the exchan...
_timestamp	2008-06-27 10:06:14
created	[InstanceEdit:354078] Garapati, P V, 2008-06-16 17:02:05
literatureReference	[LiteratureReference:354148] Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events [LiteratureReference:354156] Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
modified	[InstanceEdit:372632] Garapati, P V, 2008-06-27 10:06:12
text	Sos-1 bound to Grb2:FAK:Integrin complex promotes the exchange of inactive Ras-GDP to active Ras-GTP. RAS activation results in activation of the protein kinases RAF1, B-Raf, and MAP-ERK kinase kinase (MEKK) involved in the MAPK signaling pathway.
(summation)	[Reaction:354152] AlphaIIbbeta3 mediated nucleotide exchange of RAS (SHC) [Homo sapiens]
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No pathways have been reviewed or authored by Sos-1 bound to Grb2:FAK:Integrin complex promotes the exchan... (354058)