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Details on Person UniProt:Q90YB1 LIG4
| Class:Id | ReferenceGeneProduct:353309 |
|---|---|
| _chainChangeLog | chain:1-912 added on Sat February 7 2015 |
| _displayName | UniProt:Q90YB1 LIG4 |
| _timestamp | 2024-02-26 03:54:33 |
| chain | chain:1-912 |
| checksum | CBF2899CA76D212D |
| comment | FUNCTION DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4.CATALYTIC ACTIVITY ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.COFACTOR Interacts with XRCC4; the LIG4-XRCC4 subcomplex has a 1:2 stoichiometry (By similarity). Component of the core long-range non-homologous end joining (NHEJ) complex (also named DNA-PK complex) composed of PRKDC, LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity). Additional component of the NHEJ complex includes PAXX (By similarity). Following autophosphorylation, PRKDC dissociates from DNA, leading to formation of the short-range NHEJ complex, composed of LIG4, XRCC4, XRCC6/Ku70, XRCC5/Ku86 and NHEJ1/XLF (By similarity).SUBCELLULAR LOCATION Belongs to the ATP-dependent DNA ligase family. |
| created | [InstanceEdit:353491] Saxena, A, 2008-06-12 16:39:18 |
| description | recommendedName: fullName evidence="7"DNA ligase 4 ecNumber evidence="5"6.5.1.1 alternativeName: fullName evidence="6"DNA ligase IV alternativeName: Polydeoxyribonucleotide synthase [ATP] 4 |
| geneName | LIG4 RCJMB04_10b2 |
| identifier | Q90YB1 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell cycle Cell division DNA damage DNA recombination DNA repair Ligase Magnesium Metal-binding Nucleotide-binding Nucleus Reference proteome Repeat |
| modified | [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8964659] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9765872] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 |
| name | LIG4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | DNLI4_CHICK Q5ZKM3 |
| sequenceLength | 912 |
| species | [Species:49591] Gallus gallus |
| (referenceEntity) | [EntityWithAccessionedSequence:353461] DNA ligase IV [nucleoplasm] [Gallus gallus] |
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No pathways have been reviewed or authored by UniProt:Q90YB1 LIG4 (353309)
