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Details on Person Before rejoining of the broken DNA ends can occur, endonucle...
| Class:Id | Summation:353291 |
|---|---|
| _displayName | Before rejoining of the broken DNA ends can occur, endonucle... |
| _timestamp | 2009-02-23 15:56:29 |
| created | [InstanceEdit:353491] Saxena, A, 2008-06-12 16:39:18 |
| modified | [InstanceEdit:391641] Saxena, A, 2009-02-23 15:55:32 |
| text | Before rejoining of the broken DNA ends can occur, endonucleases removes possible 3' phospho-glycolate residues so that a DNA-PK synaptic complex with ligatable DNA is formed at the DSB. Rejoining of ionizing radiation (IR)-induced DNA DSBs usually follows biphasic kinetics with a fast (t(1/2): 5-30 min) component attributed to DNA PK dependent non homologous end joining (NHEJ) and a slow (t(1/2): 1-20 h) component of as yet uncharacterized reaction. In a systematic genetic study using the chicken DT40 cell line and employing a series of mutants defective in homologous recombination (HR), it was suggested that NHEJ is the main pathway for rejoining of IR-induced DNA DSBs in vertebrates. It is speculated that the contribution of homologous recombination repair (HRR) occurs at a stage after the initial rejoining. |
| (summation) | [Reaction:353313] Removal of 3'-phosphoglycolate (PG) moiety from DSB ends [Gallus gallus] |
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No pathways have been reviewed or authored by Before rejoining of the broken DNA ends can occur, endonucle... (353291)
