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Details on Person Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase

Class:Id	Reaction:353277
_displayName	Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase
_doRelease	TRUE
_timestamp	2011-11-23 11:16:41
authored	[InstanceEdit:399969] Saxena, A, 2008-07-07 18:55:16
catalystActivity	[CatalystActivity:418653] DNA N-glycosylase activity of TDG [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:353491] Saxena, A, 2008-06-12 16:39:18
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input	[Complex:353305] 5-methylcytosine glycosylase:thymine complex [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:353427] 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence [LiteratureReference:353319] Mechanisms of DNA demethylation in chicken embryos. Purification and properties of a 5-methylcytosine-DNA glycosylase
modified	[InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19 [InstanceEdit:399968] D'Eustachio, P, 2009-03-23 22:14:23 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 [InstanceEdit:418622] D'Eustachio, P, 2009-04-24 16:21:33 [InstanceEdit:418633] D'Eustachio, P, 2009-04-24 22:33:38 [InstanceEdit:418655] D'Eustachio, P, 2009-04-25 18:25:27 [InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45 [InstanceEdit:1670463] D'Eustachio, P, 2011-10-15 [InstanceEdit:1892047] D'Eustachio, P, 2011-11-01 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Cleavage of thymine by 5-methylcytosine G/T mismatch specific glycosylase
output	[Complex:353249] DNA containing a 5-methylcytosine glycosylase-bound apurinic/apyrimidinic site [nucleoplasm] [Gallus gallus] [SimpleEntity:29692] Thy [nucleoplasm]
precedingEvent	[Reaction:353481] 5-methylcytosine G/T mismatch specific DNA glycosylase mediated recognition and binding of thymine opposite guanine at CpG sequences [Gallus gallus]
releaseDate	2009-06-01
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016677] R-GGA-353277.2
summation	[Summation:353264] This reaction takes place in the 'nucleus' and is mediated b...
(hasEvent)	[Pathway:353234] Base Excision Repair, AP site formation by depyrimidination [Gallus gallus]
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