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Details on Person Monoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site

Class:IdReaction:353243
_displayNameMonoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site
_doReleaseTRUE
_timestamp2024-07-16 19:49:44
authored[InstanceEdit:399969] Saxena, A, 2008-07-07 18:55:16
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:353491] Saxena, A, 2008-06-12 16:39:18
edited[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input[EntityWithAccessionedSequence:353448] POLH [nucleoplasm] [Gallus gallus]
[OtherEntity:109939] damaged DNA substrate [nucleoplasm]
[Complex:353521] Pol zeta complex [nucleoplasm] [Gallus gallus]
literatureReference[LiteratureReference:353396] A role for PCNA ubiquitination in immunoglobulin hypermutation
[LiteratureReference:353203] RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells
[LiteratureReference:353523] A novel Rad18 function involved in protection of the vertebrate genome after exposure to camptothecin
[LiteratureReference:353320] Involvement of Rad18 in somatic hypermutation
[LiteratureReference:353294] Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells
modified[InstanceEdit:374078] Saxena, A, 2008-07-25 17:02:19
[InstanceEdit:399968] D'Eustachio, P, 2009-03-23 22:14:23
[InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00
[InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07
[InstanceEdit:418645] D'Eustachio, P, 2009-04-25 16:42:20
[InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45
[InstanceEdit:426283] D'Eustachio, P, 2009-06-15
[InstanceEdit:1670463] D'Eustachio, P, 2011-10-15
[InstanceEdit:1892047] D'Eustachio, P, 2011-11-01
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9915824] D'Eustachio, Peter, 2024-07-16
nameMonoubiquitunated PCNA mediates recruitment of the translesion polymerase to the DNA damaged site
output[Complex:353270] Pol eta -DNA damage complex [nucleoplasm] [Gallus gallus]
[Complex:353297] Pol zeta-damaged DNA complex [nucleoplasm] [Gallus gallus]
precedingEvent
regulatedBy[PositiveRegulation:426285] Positive regulation by 'monoubiquitinated PCNA [nucleoplasm]'
releaseDate2009-06-01
reviewed[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:49591] Gallus gallus
stableIdentifier[StableIdentifier:2016713] R-GGA-353243.4
summation[Summation:353376] Proliferating cell nuclear antigen (PCNA) is a DNA polymeras...
(hasEvent)[Pathway:353299] RAD18 and ubiquitinated PCNA-mediated recruitment of translesion polymerases [Gallus gallus]
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