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Details on Person pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate

Class:Id	Reaction:353154
_displayName	pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate
_doRelease	TRUE
_timestamp	2011-11-23 11:07:14
authored	[InstanceEdit:376875] D'Eustachio, P, 2008-09-10 19:15:11
catalystActivity	[CatalystActivity:353148] pyruvate carboxylase activity of PYC [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:353166] D'Eustachio, P, 2008-06-11 19:28:03
edited	[InstanceEdit:376875] D'Eustachio, P, 2008-09-10 19:15:11
input	[SimpleEntity:113557] PYR [mitochondrial matrix] [SimpleEntity:29376] CO2 [mitochondrial matrix] [SimpleEntity:113593] ATP [mitochondrial matrix]
literatureReference	[LiteratureReference:353160] Molecular cloning and domain structure of chicken pyruvate carboxylase [LiteratureReference:353153] Pyruvate carboxylase. II. Properties [LiteratureReference:353150] Pyruvate carboxylase. IX. Some properties of the activation by certain acyl derivatives of coenzyme A
modified	[InstanceEdit:372360] D'Eustachio, P, 2008-06-20 18:34:57 [InstanceEdit:372605] D'Eustachio, P, 2008-06-26 22:24:19 [InstanceEdit:372851] D'Eustachio, P, 2008-07-07 21:23:41 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418568] D'Eustachio, P, 2009-04-23 19:25:43 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	pyruvate + CO2 + ATP => oxaloacetate + ADP + orthophosphate Carboxylation of pyruvate to form oxaloacetate
output	[SimpleEntity:113581] ADP [mitochondrial matrix] [SimpleEntity:113548] Pi [mitochondrial matrix] [SimpleEntity:113587] OA [mitochondrial matrix]
precedingEvent	[Reaction:372359] pyruvate + H+ [cytosol] => pyruvate + H+ [mitochondrial matrix] [Gallus gallus] [Reaction:353056] phosphoenolpyruvate + ADP => pyruvate + ATP [Gallus gallus] [Reaction:372903] lactate + NAD+ <=> pyruvate + NADH + H+ [Gallus gallus]
regulatedBy	[Requirement:354222] Requirement by 'Mg2+ [mitochondrial matrix]' [Requirement:354223] Requirement by 'Ac-CoA [mitochondrial matrix]'
releaseDate	2009-06-01
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016212] R-GGA-353154.3
summation	[Summation:353159] Pyruvate carboxylase catalyzes the reaction of pyruvate, ATP...
(hasEvent)	[Pathway:352875] Gluconeogenesis [Gallus gallus]
(precedingEvent)	[Reaction:372422] oxaloacetate + NADH + H+ <=> malate + NAD+ [Gallus gallus] [Reaction:372564] oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate (2-oxoglutarate) [Gallus gallus] [Reaction:372724] oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] [Gallus gallus]
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