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Details on Person Cytosolic phosphofructokinase 1 (PFK1) catalyzes the irrever...
| Class:Id | Summation:352902 |
|---|---|
| _displayName | Cytosolic phosphofructokinase 1 (PFK1) catalyzes the irrever... |
| _timestamp | 2008-06-24 22:10:14 |
| created | [InstanceEdit:352922] D'Eustachio, P, 2008-06-09 12:49:16 |
| modified | [InstanceEdit:372435] D'Eustachio, P, 2008-06-24 22:10:18 |
| text | Cytosolic phosphofructokinase 1 (PFK1) catalyzes the irreversible reaction of fructose 6-phosphate and ATP to form fructose 1,6-bisphosphate and ADP in a reaction that is positively regulated by fructose 2,6-bisphosphate (Chaekal et al. 1983). In rodents and humans, two major isoforms of the enzyme are differentially regulated to meet tissue-specific requirements for glucose breakdown in response to the organism's nutritional status and need to support vigorous muscle activity. Chicken genes predicted to encode proteins similar to human liver and muscle PFK1 isoforms have been shown to be differentially expressed in chicken tissues and in response to insulin. The physiological consequences of their differential expression are unknown (Seki et al. 2006). Five additional proteins, PFK1-like1, 2, 3, 4, and 5, are predicted to have phosphofructokinase 1 activity based on OrthoMCL analysis of the ENSEMBL chicken gene set. |
| (summation) | [Reaction:352945] fructose 6-phosphate + ATP => fructose 1,6-bisphosphate + ADP [Gallus gallus] |
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No pathways have been reviewed or authored by Cytosolic phosphofructokinase 1 (PFK1) catalyzes the irrever... (352902)
