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Query author contributions in Reactome

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Details on Person UniProt:P00548 PKM

Class:IdReferenceGeneProduct:352830
_chainChangeLoginitiator methionine:1 added on Sat February 7 2015;chain:2-530 added on Sat February 7 2015;initiator methionine:1 for 352830 removed on Fri Nov 03 2023;initiator methionine: for 352830 added on Fri Nov 03 2023;initiator methionine: for 352830 removed on Fri Aug 15 2025;initiator methionine:1 for 352830 added on Fri Aug 15 2025
_displayNameUniProt:P00548 PKM
_timestamp2025-08-15 22:01:29
chaininitiator methionine:1
chain:2-530
checksum8B0DF09FD82EB72F
commentFUNCTION Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP.CATALYTIC ACTIVITY pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)COFACTOR Allosterically activated by fructose 1,6-bisphosphate.PATHWAY Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.SUBUNIT Homotetramer.MISCELLANEOUS This activity is regulated by glucose levels.SIMILARITY Belongs to the pyruvate kinase family.
created[InstanceEdit:352820] D'Eustachio, P, 2008-06-08 15:23:54
descriptionrecommendedName: Pyruvate kinase PKM ecNumber evidence="3"2.7.1.40
geneNamePKM
identifierP00548
isSequenceChangedFALSE
keywordAllosteric enzyme
ATP-binding
Glycolysis
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Potassium
Pyruvate
Reference proteome
Transferase
modified[InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18
[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
[InstanceEdit:423310] Kanapin, AA
[InstanceEdit:435478] Kanapin, AA
[InstanceEdit:435871] Kanapin, AA
[InstanceEdit:447347] Kanapin, AA
[InstanceEdit:525883] Kanapin, AA
[InstanceEdit:613449] Kanapin, AA
[InstanceEdit:797602] Kanapin, AA
[InstanceEdit:937368] Yung, CK
[InstanceEdit:1042053] Yung, CK
[InstanceEdit:1220657] Yung, CK
[InstanceEdit:1300696] Yung, CK
[InstanceEdit:1301627] Yung, CK
[InstanceEdit:1551960] Weiser, JD
[InstanceEdit:1995863] Weiser, JD
[InstanceEdit:2132304] Weiser, JD
[InstanceEdit:2265580] Weiser, JD
[InstanceEdit:2587579] Weiser, JD
[InstanceEdit:4341137] Weiser, JD
[InstanceEdit:5433710] Weiser, JD
[InstanceEdit:5618415] Weiser, JD
[InstanceEdit:5634237] Weiser, JD
[InstanceEdit:5673015] Weiser, JD
[InstanceEdit:9037114] Weiser, JD
[InstanceEdit:9627708] Weiser, JD
[InstanceEdit:9637257] Weiser, JD
[InstanceEdit:9676415] Weiser, JD
[InstanceEdit:9698430] Weiser, JD
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
namePKM
referenceDatabase[ReferenceDatabase:2] UniProt
secondaryIdentifierKPYM_CHICK
sequenceLength530
species[Species:49591] Gallus gallus
(referenceEntity)[EntityWithAccessionedSequence:353053] PKM2 [cytosol] [Gallus gallus]
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No pathways have been reviewed or authored by UniProt:P00548 PKM (352830)