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Details on Person SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine

Class:Id	Reaction:352354
_displayName	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
_doRelease	TRUE
_timestamp	2025-08-14 07:43:31
authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:352361] amino acid transmembrane transporter activity of SLC1A4 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352351] D'Eustachio, P, 2008-06-02 18:13:12
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
input	[DefinedSet:352355] alanine, serine, threonine, or cysteine [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:352016] Cys [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:352345] ASCT-1 is a neutral amino acid exchanger with chloride channel activity [LiteratureReference:352362] Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family [LiteratureReference:352348] Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters
modified	[InstanceEdit:352392] D'Eustachio, P, 2008-06-02 20:14:17 [InstanceEdit:352499] D'Eustachio, P, 2008-06-03 13:08:24 [InstanceEdit:602192] D'Eustachio, P, 2010-04-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9963210] Stephan, Ralf, 2025-08-13 [InstanceEdit:9963282] Stephan, Ralf, 2025-08-14 [InstanceEdit:9963335] Stephan, Ralf, 2025-08-14 [InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
name	SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
negativePrecedingEvent	[NegativePrecedingEvent:9963209] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine [NegativePrecedingEvent:9963220] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963316] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963318] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963294] Futile Cycle: SLC36A1-mediated uptake of glycine, proline, and alanine [NegativePrecedingEvent:9963363] Futile Cycle: SLC38A1 (ATA1)-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963356] Futile Cycle: SLC38A2 (ATA2)-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963364] Futile Cycle: SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine [NegativePrecedingEvent:9963338] Futile Cycle: SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine [NegativePrecedingEvent:9963357] Futile Cycle: SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963361] Futile Cycle: SLC6A15-mediated amino acid uptake [NegativePrecedingEvent:9963396] Futile Cycle: SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol [NegativePrecedingEvent:9963401] Futile Cycle: SLC7A10-mediated uptake of small neutral amino acids [NegativePrecedingEvent:9963429] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963377] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids
output	[DefinedSet:352359] alanine, serine, threonine, or cysteine [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:111707] L-Cys [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2008-06-30
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360265] R-HSA-352354.3
summation	[Summation:352374] SLC1A4, associated with the plasma membrane, mediates the ex...
(hasEvent)	[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963204] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963205] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963206] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963207] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963208] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963213] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963215] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963218] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963219] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963221] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine List all 15 refering instances
(replacementInstances)	[_Deleted:602193] Deletion of instance: 352370
(updatedInstance)	[_UpdateTracker:9790711] Update Tracker - [Reaction:352354] SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine - v33:[addLiteratureReference]
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