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Details on Person SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol

Class:Id	Reaction:352232
_displayName	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol
_doRelease	TRUE
_timestamp	2025-08-14 07:46:24
authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:352233] L-amino acid transmembrane transporter activity of SLC7A5:SLC3A2 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352226] D'Eustachio, P, 2008-06-02 00:48:27
crossReference	[DatabaseIdentifier:9917062] RHEA:73011 [DatabaseIdentifier:9917063] RHEA:29703 [DatabaseIdentifier:9929648] RHEA:68572 [DatabaseIdentifier:9929649] RHEA:72807 [DatabaseIdentifier:9929639] RHEA:70947 [DatabaseIdentifier:9929646] RHEA:27950 [DatabaseIdentifier:9929644] RHEA:70939 [DatabaseIdentifier:9917055] RHEA:70943 [DatabaseIdentifier:9929643] RHEA:70719
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
goBiologicalProcess	[GO_BiologicalProcess:5083556] L-alpha-amino acid transmembrane transport
input	[DefinedSet:352229] ligands of SLC7A5 [extracellular region]
literatureReference	[LiteratureReference:352225] Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function [LiteratureReference:352184] Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids [LiteratureReference:9929614] Functional characterization of tyrosine transport in fibroblast cells from healthy controls
modified	[InstanceEdit:352392] D'Eustachio, P, 2008-06-02 20:14:17 [InstanceEdit:352499] D'Eustachio, P, 2008-06-03 13:08:24 [InstanceEdit:8939588] Jassal, Bijay, 2016-09-20 [InstanceEdit:8949420] D'Eustachio, Peter, 2016-11-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9929610] D'Eustachio, Peter, 2024-11-26 [InstanceEdit:9929640] D'Eustachio, Peter, 2024-11-27 [InstanceEdit:9963210] Stephan, Ralf, 2025-08-13 [InstanceEdit:9963282] Stephan, Ralf, 2025-08-14 [InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
name	SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol L-leucine(in) = L-leucine(out) L-valine(in) = L-valine(out) L-tyrosine(in) = L-tyrosine(out) L-histidine(in) = L-histidine(out) L-tryptophan(in) = L-tryptophan(out) L-phenylalanine(in) = L-phenylalanine(out) L-methionine(in) = L-methionine(out) L-isoleucine(in) = L-isoleucine(out) L-alanine(in) = L-alanine(out)
negativePrecedingEvent	[NegativePrecedingEvent:9963225] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine [NegativePrecedingEvent:9963221] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963311] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963296] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963319] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane [NegativePrecedingEvent:9963428] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
output	[DefinedSet:352227] ligands of SLC7A5 [cytosol]
releaseDate	2008-06-30
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360449] R-HSA-352232.6
summation	[Summation:352231] SLC7A5, complexed with SLC3A2 in the plasma membrane, mediat...
(hasEvent)	[Pathway:71240] Tryptophan catabolism [Homo sapiens] [Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963371] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963376] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963386] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963405] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963418] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963429] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [NegativePrecedingEvent:9963601] Futile Cycle: SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol [Reaction:71188] TDO tetramer dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:198563] IDO1 dioxygenates L-Trp to NFK [Homo sapiens] [Reaction:888614] IDO2 dioxygenates L-Trp to NFK [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9939756] Update Tracker - [Reaction:352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - v92:[modifyText, removeLiteratureReference]
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