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Details on Person SLC7A8-mediated uptake of neutral amino acids

Class:Id	Reaction:352191
_displayName	SLC7A8-mediated uptake of neutral amino acids
_doRelease	TRUE
_timestamp	2025-08-14 07:46:57
authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:352154] amino acid transmembrane transporter activity of SLC7A8:SLC3A2 heterodimer [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643532] amino acid transmembrane transporter activity of SLC7A8:SLC3A2 heterodimer [plasma membrane] Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:352192] D'Eustachio, P, 2008-06-01 17:38:36
crossReference	[DatabaseIdentifier:9917062] RHEA:73011 [DatabaseIdentifier:9917063] RHEA:29703 [DatabaseIdentifier:9929648] RHEA:68572 [DatabaseIdentifier:9929649] RHEA:72807 [DatabaseIdentifier:9929639] RHEA:70947 [DatabaseIdentifier:9929646] RHEA:27950 [DatabaseIdentifier:9929644] RHEA:70939 [DatabaseIdentifier:9917055] RHEA:70943 [DatabaseIdentifier:9929643] RHEA:70719
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
input	[DefinedSet:352193] ligands of SLC7A8 [extracellular region]
literatureReference	[LiteratureReference:352184] Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids [LiteratureReference:352189] Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule
modified	[InstanceEdit:352234] D'Eustachio, P, 2008-06-02 00:48:44 [InstanceEdit:352392] D'Eustachio, P, 2008-06-02 20:14:17 [InstanceEdit:352499] D'Eustachio, P, 2008-06-03 13:08:24 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9960042] Stephan, Ralf, 2025-07-06 [InstanceEdit:9963210] Stephan, Ralf, 2025-08-13 [InstanceEdit:9963282] Stephan, Ralf, 2025-08-14 [InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
name	SLC7A8-mediated uptake of neutral amino acids
negativePrecedingEvent	[NegativePrecedingEvent:9963230] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine [NegativePrecedingEvent:9963226] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine [NegativePrecedingEvent:9963305] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine [NegativePrecedingEvent:9963290] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine [NegativePrecedingEvent:9963298] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane [NegativePrecedingEvent:9963309] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane [NegativePrecedingEvent:9963372] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
output	[DefinedSet:352190] ligands of SLC7A8 [cytosol]
releaseDate	2008-06-30
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358940] R-HSA-352191.4
summation	[Summation:352194] SLC7A8, complexed with SLC3A2 in the plasma membrane, mediat...
(hasEvent)	[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9963377] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963378] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963397] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963398] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963402] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963411] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963427] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids [NegativePrecedingEvent:9963593] Futile Cycle: SLC7A8-mediated uptake of neutral amino acids
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No pathways have been reviewed or authored by SLC7A8-mediated uptake of neutral amino acids (352191)