Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person SLC6A15-mediated amino acid uptake

Class:IdReaction:352059
_displayNameSLC6A15-mediated amino acid uptake
_doReleaseTRUE
_timestamp2025-08-14 07:45:22
authored[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity[CatalystActivity:352062] amino acid transmembrane transporter activity of SLC6A15 [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:352063] D'Eustachio, P, 2008-05-30 00:13:57
crossReference[DatabaseIdentifier:9956823] RHEA:29265
[DatabaseIdentifier:9956828] RHEA:29277
[DatabaseIdentifier:9956842] RHEA:68241
[DatabaseIdentifier:9956831] RHEA:28969
[DatabaseIdentifier:9956846] RHEA:29285
[DatabaseIdentifier:9956819] RHEA:71385
[DatabaseIdentifier:9956829] RHEA:29269
[DatabaseIdentifier:9956818] RHEA:68234
[DatabaseIdentifier:9956837] RHEA:68238
[DatabaseIdentifier:9956843] RHEA:29577
[DatabaseIdentifier:9956844] RHEA:70001
edited[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
input[DefinedSet:352051] ligands of SLC6A15 [extracellular region]
[SimpleEntity:74113] Na+ [extracellular region]
literatureReference[LiteratureReference:352050] Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain
modified[InstanceEdit:352065] D'Eustachio, P, 2008-05-30 00:16:48
[InstanceEdit:352392] D'Eustachio, P, 2008-06-02 20:14:17
[InstanceEdit:352499] D'Eustachio, P, 2008-06-03 13:08:24
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9956833] Stephan, Ralf, 2025-06-14
[InstanceEdit:9963210] Stephan, Ralf, 2025-08-13
[InstanceEdit:9963282] Stephan, Ralf, 2025-08-14
[InstanceEdit:9963370] Stephan, Ralf, 2025-08-14
nameSLC6A15-mediated amino acid uptake
negativePrecedingEvent[NegativePrecedingEvent:9963222] Futile Cycle: SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine
[NegativePrecedingEvent:9963208] Futile Cycle: SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine
[NegativePrecedingEvent:9963304] Futile Cycle: SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine
[NegativePrecedingEvent:9963277] Futile Cycle: SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine
[NegativePrecedingEvent:9963292] Futile Cycle: SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane
[NegativePrecedingEvent:9963273] Futile Cycle: SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane
[NegativePrecedingEvent:9963410] Futile Cycle: SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu
output[DefinedSet:352048] ligands of SLC6A15 [cytosol]
[SimpleEntity:83910] Na+ [cytosol]
releaseDate2008-06-30
reviewed[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360070] R-HSA-352059.3
summation[Summation:352056] SLC6A15, associated with the plasma membrane, mediates the u...
(hasEvent)[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens]
[Pathway:442660] SLC-mediated transport of neurotransmitters [Homo sapiens]
(precedingEvent)[NegativePrecedingEvent:9963345] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963346] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963348] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963350] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963352] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963361] Futile Cycle: SLC6A15-mediated amino acid uptake
[NegativePrecedingEvent:9963421] Futile Cycle: SLC6A15-mediated amino acid uptake
[Change default viewing format]
No pathways have been reviewed or authored by SLC6A15-mediated amino acid uptake (352059)