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Details on Person SLC6A12 (BGT-1)-mediated uptake of GABA and betaine

Class:Id	Reaction:352029
_displayName	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
_doRelease	TRUE
_timestamp	2025-06-14 15:02:54
authored	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
catalystActivity	[CatalystActivity:351984] amino acid transmembrane transporter activity of SLC6A12 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:352012] D'Eustachio, P, 2008-05-29 20:27:07
crossReference	[DatabaseIdentifier:9956813] RHEA:71176
edited	[InstanceEdit:352382] D'Eustachio, P, 2008-06-02 20:10:30
input	[DefinedSet:352007] ligands of SLC6A12 (BGT-1) [extracellular region] [SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:188972] Cl- [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region] [SimpleEntity:74113] Na+ [extracellular region]
literatureReference	[LiteratureReference:352038] Functional characterization of the Betaine/gamma-aminobutyric acid transporter BGT-1 expressed in Xenopus oocytes [LiteratureReference:351985] Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney
modified	[InstanceEdit:352392] D'Eustachio, P, 2008-06-02 20:14:17 [InstanceEdit:352499] D'Eustachio, P, 2008-06-03 13:08:24 [InstanceEdit:918010] Mahajan, SS, 2010-07-30 [InstanceEdit:918261] Mahajan, SS, 2010-08-03 [InstanceEdit:936520] Mahajan, SS, 2010-08-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9956811] Stephan, Ralf, 2025-06-14
name	SLC6A12 (BGT-1)-mediated uptake of GABA and betaine
output	[DefinedSet:351982] ligands of SLC6A12 (BGT-1) [cytosol] [SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:352022] Cl- [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol] [SimpleEntity:83910] Na+ [cytosol]
releaseDate	2008-06-30
reviewed	[InstanceEdit:352498] Jassal, Bijay, 2008-06-03
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:918258] Mahajan, SS, 2010-08-03
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359695] R-HSA-352029.3
summation	[Summation:352004] The plasma membrane transport protein SLC6A12 (BGT-1) mediat...
(hasEvent)	[Pathway:352230] Amino acid transport across the plasma membrane [Homo sapiens] [Pathway:888593] Reuptake of GABA [Homo sapiens]
(precedingEvent)	[Reaction:888592] Loading of GABA into clathrin sculpted GABA transport vesicle lumen [Homo sapiens]
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