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Details on Person Caspase-mediated cleavage of Desmoglein 2

Class:Id	Reaction:351877
_displayName	Caspase-mediated cleavage of Desmoglein 2
_doRelease	TRUE
_timestamp	2017-11-24 15:42:01
authored	[InstanceEdit:352235] Schulze-Osthoff, K, 2008-05-18 10:00:05
catalystActivity	[CatalystActivity:114327] cysteine-type endopeptidase activity of Caspase-3 [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:351919] Matthews, L, 2008-05-28 22:38:42
edited	[InstanceEdit:201589] Matthews, L, 2007-09-03 07:38:20 [InstanceEdit:201989] Matthews, L, 2007-10-09 13:44:38 [InstanceEdit:350331] Matthews, L, 2008-05-18 15:44:16
input	[EntityWithAccessionedSequence:351896] DSG2 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:351838] The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery
modified	[InstanceEdit:351926] Matthews, L, 2008-05-28 22:50:03 [InstanceEdit:352239] Matthews, L, 2008-06-02 07:41:19 [InstanceEdit:352465] Matthews, L, 2008-06-03 00:23:29 [InstanceEdit:352491] Matthews, L, 2008-06-03 01:13:58 [InstanceEdit:353176] Matthews, L, 2008-06-12 00:23:53 [InstanceEdit:353640] Matthews, L, 2008-06-13 11:27:03 [InstanceEdit:9029450] Orlic-Milacic, Marija, 2017-11-17 [InstanceEdit:9029992] Orlic-Milacic, Marija, 2017-11-24 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Caspase-mediated cleavage of Desmoglein 2
output	[EntityWithAccessionedSequence:351839] DSG2(?-1118) [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:114252] Cleavage of Procaspase-3 by the apoptosome [Homo sapiens] [Reaction:114259] Cleavage of Procaspase‑9 to caspase‑9 [Homo sapiens] [Reaction:114419] Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 [Homo sapiens] [Reaction:114306] SMAC binds XIAP:Caspase-3 [Homo sapiens] [Reaction:418845] Activation of caspase-3 [Homo sapiens] [Reaction:373700] Caspase-9 binds DCC:DIP13alpha complex [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:350641] Ranganathan, S, 2008-06-11 19:13:33
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360104] R-HSA-351877.3
summation	[Summation:352240] In apoptotic cells, intercellular contacts are disrupted th...
(hasEvent)	[Pathway:351906] Apoptotic cleavage of cell adhesion proteins [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9779894] Update Tracker - [Reaction:351877] Caspase-mediated cleavage of Desmoglein 2 - v64:[add_removeCatalystActivity]
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