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Details on Person Cleavage of the C-terminal cytoplasmic domain of occludin d...
| Class:Id | Summation:351831 |
|---|---|
| _displayName | Cleavage of the C-terminal cytoplasmic domain of occludin d... |
| _timestamp | 2017-11-21 20:33:35 |
| created | [InstanceEdit:351919] Matthews, L, 2008-05-28 22:38:42 |
| literatureReference | [LiteratureReference:351914] The specific fates of tight junction proteins in apoptotic epithelial cells [LiteratureReference:9029702] Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage [LiteratureReference:9029707] The role of caspase-3 in lipopolysaccharide-mediated disruption of intestinal epithelial tight junctions |
| modified | [InstanceEdit:351930] Matthews, L, 2008-05-28 22:51:50 [InstanceEdit:3877114] D'Eustachio, P, 2013-07-10 [InstanceEdit:4393425] Orlic-Milacic, M, 2013-08-22 [InstanceEdit:9029712] Orlic-Milacic, Marija, 2017-11-21 [InstanceEdit:9029725] Orlic-Milacic, Marija, 2017-11-21 |
| text | Cleavage of the C-terminal cytoplasmic domain of occludin during apoptosis generates a fragment that can no longer associate with the cytoplasmic adapter proteins ZO-1, -2 and -3 and, as a consequence, with the actin cytoskeleton (Bojarski et al., 2003). Cleavage of ZO-1 and ZO-2 further disrupts tight junction structure and function. Notably, claudins, which are associated with ZO-1, ZO-2 and ZO-3, completely lose their linkage to the actin cytoskeleton and other ZO-1-, ZO-2-, ZO-3-interacting proteins (Bojarski et al., 2003). Caspase-3 was found to be responsible for TJP1 (ZO-1) cleavage in both dog and mouse cells (Chin et al. 2006, Zehendner et al. 2011). |
| (summation) | [Reaction:351913] Caspase-mediated cleavage of TJP1 [Homo sapiens] |
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No pathways have been reviewed or authored by Cleavage of the C-terminal cytoplasmic domain of occludin d... (351831)
