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Details on Person Association of MRE11 with RAD50

Class:Id	Reaction:351407
_displayName	Association of MRE11 with RAD50
_doRelease	TRUE
_timestamp	2011-11-23 11:06:20
authored	[InstanceEdit:399969] Saxena, A, 2008-07-07 18:55:16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:351413] Saxena, A, 2008-05-22 20:44:09
edited	[InstanceEdit:418967] D'Eustachio, P, 2009-04-27 17:09:41
input	[EntityWithAccessionedSequence:217092] MRE11A [nucleoplasm] [Gallus gallus] [EntityWithAccessionedSequence:217028] RAD50 [nucleoplasm] [Gallus gallus]
literatureReference	[LiteratureReference:216980] Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks [LiteratureReference:217187] The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions [LiteratureReference:265795] The forkhead-associated domain of NBS1 is essential for nuclear foci formation after irradiation but not essential for hRAD50[middle dot]hMRE11[middle dot]NBS1 complex DNA repair activity
modified	[InstanceEdit:351443] Saxena, A, 2008-05-22 20:44:57 [InstanceEdit:399968] D'Eustachio, P, 2009-03-23 22:14:23 [InstanceEdit:418476] D'Eustachio, P, 2009-04-22 20:40:00 [InstanceEdit:418618] D'Eustachio, P, 2009-04-24 15:53:07 [InstanceEdit:418966] D'Eustachio, P, 2009-04-27 17:13:45 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of MRE11 with RAD50
output	[Complex:351422] MRE11-RAD50 complex [nucleoplasm] [Gallus gallus]
releaseDate	2009-06-01
reviewed	[InstanceEdit:418616] Borowiec, JA, 2009-04-23 20:19:22
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:49591] Gallus gallus
stableIdentifier	[StableIdentifier:2016167] R-GGA-351407.2
summation	[Summation:351420] MRE11 and RAD50 are homologs of proteins first identified in...
(hasEvent)	[Pathway:351444] Recruitment of repair and signaling proteins to double-strand breaks [Gallus gallus]
(precedingEvent)	[Reaction:351412] Association of MRE11 and NBS1 leads to nuclear localization of MRN complex [Gallus gallus]
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No pathways have been reviewed or authored by Association of MRE11 with RAD50 (351407)