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Details on Person Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine

Class:Id	Reaction:351215
_displayName	Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine
_doRelease	TRUE
_timestamp	2025-11-21 18:38:22
authored	[InstanceEdit:351144] Gopinathrao, G, 2008-05-21 15:52:50
catalystActivity	[CatalystActivity:351209] spermidine synthase activity of SRM [cytosol]
catalystActivityReference	[CatalystActivityReference:9955587] spermidine synthase activity of SRM [cytosol] Structure and mechanism of spermidine synthases
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9955566] RHEA:12722
edited	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
input	[SimpleEntity:29610] Putrescine [cytosol] [SimpleEntity:353113] dc-AdoMet [cytosol]
internalReviewed	[InstanceEdit:9955817] D'Eustachio, Peter, 2025-06-11
literatureReference	[LiteratureReference:353577] Human spermidine synthase gene: structure and chromosomal localization [LiteratureReference:9955554] Structure and mechanism of spermidine synthases
modified	[InstanceEdit:351232] Gopinathrao, G, 2008-05-21 20:55:59 [InstanceEdit:352212] Gopinathrao, G, 2008-06-02 00:29:22 [InstanceEdit:353132] Gopinathrao, G, 2008-06-11 17:15:22 [InstanceEdit:353581] Gopinathrao, G, 2008-06-12 17:22:59 [InstanceEdit:354047] Gopinathrao, G, 2008-06-16 14:42:34 [InstanceEdit:377479] Gopinathrao, G, 2008-09-12 14:46:34 [InstanceEdit:377671] Gopinathrao, G, 2008-09-15 23:37:39 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9955584] D'Eustachio, Peter, 2025-06-10 [InstanceEdit:9955818] D'Eustachio, Peter, 2025-06-11 [InstanceEdit:9974435] D'Eustachio, Peter, 2025-11-21
name	Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine S-adenosyl 3-(methylsulfanyl)propylamine + putrescine => S-methyl-5'-thioadenosine + spermidine + H(+)
output	[SimpleEntity:353106] MTAD [cytosol] [SimpleEntity:204635] SPM [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 [Homo sapiens] [Reaction:174391] MAT1A multimers transfer Ado from ATP to L-Met [Homo sapiens] [Reaction:70692] ornithine => putrescine + CO2 [Homo sapiens] [Reaction:9955574] ODC dimerizes [Homo sapiens] [Reaction:350604] Agmatine + H2O <=> putrescine + urea [Homo sapiens] [Reaction:350598] Arginine<=>Agmatine+CO2 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2008-09-30
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38 [InstanceEdit:9974434] D'Eustachio, Peter, 2025-11-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:377913] R-HSA-351215.4
structureModified	[InstanceEdit:9955584] D'Eustachio, Peter, 2025-06-10
summation	[Summation:353553] Spermidine synthase (SRM) carries out the final step of sper...
(hasEvent)	[Pathway:351202] Metabolism of polyamines [Homo sapiens]
(precedingEvent)	[Reaction:351208] Spermidine => N-acetylated spermidine [Homo sapiens] [Reaction:351210] dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine [Homo sapiens] [Reaction:1237160] MTA is cleaved and phosphorylated [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9964615] Update Tracker - [Reaction:351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine - v94:[modifyText, removeLiteratureReference, removeOutput]
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