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Details on Person Spermidine => N-acetylated spermidine

Class:Id	Reaction:351208
_displayName	Spermidine => N-acetylated spermidine
_doRelease	TRUE
_timestamp	2025-06-11 16:07:05
authored	[InstanceEdit:351144] Gopinathrao, G, 2008-05-21 15:52:50
catalystActivity	[CatalystActivity:351231] diamine N-acetyltransferase activity of SAT1 [cytosol]
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:9955563] RHEA:28151
edited	[InstanceEdit:179407] Gopinathrao, G, 2006-04-27 13:13:48
input	[SimpleEntity:204635] SPM [cytosol] [SimpleEntity:76183] Ac-CoA [cytosol]
internalReviewed	[InstanceEdit:9955817] D'Eustachio, Peter, 2025-06-11
literatureReference	[LiteratureReference:353571] Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase [LiteratureReference:353548] Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells
modified	[InstanceEdit:351232] Gopinathrao, G, 2008-05-21 20:55:59 [InstanceEdit:351239] Gopinathrao, G, 2008-05-21 20:59:40 [InstanceEdit:352218] Gopinathrao, G, 2008-06-02 00:44:24 [InstanceEdit:353132] Gopinathrao, G, 2008-06-11 17:15:22 [InstanceEdit:353581] Gopinathrao, G, 2008-06-12 17:22:59 [InstanceEdit:354047] Gopinathrao, G, 2008-06-16 14:42:34 [InstanceEdit:377464] Gopinathrao, G, 2008-09-12 14:45:23 [InstanceEdit:377671] Gopinathrao, G, 2008-09-15 23:37:39 [InstanceEdit:565780] D'Eustachio, P, 2010-04-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9955584] D'Eustachio, Peter, 2025-06-10 [InstanceEdit:9955818] D'Eustachio, Peter, 2025-06-11
name	Spermidine => N-acetylated spermidine spermidine + acetyl-CoA => N(1)-acetylspermidine + CoA + H(+)
output	[SimpleEntity:353555] NASPM [cytosol] [SimpleEntity:76194] CoA-SH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:351215] Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine [Homo sapiens] [Reaction:351222] S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2 [Homo sapiens] [Reaction:70692] ornithine => putrescine + CO2 [Homo sapiens] [Reaction:350604] Agmatine + H2O <=> putrescine + urea [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2008-09-30
reviewed	[InstanceEdit:377465] D'Eustachio, P, 2008-06-12 14:43:38
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:377941] R-HSA-351208.3
structureModified	[InstanceEdit:9955584] D'Eustachio, Peter, 2025-06-10
summation	[Summation:353547] Spermidine/spermine N1-acetyltransferase (SAT1, also known a...
(hasEvent)	[Pathway:351200] Interconversion of polyamines [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:351201] N-acetylated spermidine (cytosol)=>N-acetylated spermidine (peroxisomal) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790430] Update Tracker - [Reaction:351208] Spermidine => N-acetylated spermidine - v33:[addOutput] [_UpdateTracker:9964767] Update Tracker - [Reaction:351208] Spermidine => N-acetylated spermidine - v94:[modifyText, removeOutput]
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No pathways have been reviewed or authored by Spermidine => N-acetylated spermidine (351208)