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Details on Person LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D

Class:Id	Reaction:350168
_displayName	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
_doRelease	TRUE
_timestamp	2025-07-03 21:44:31
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:350169] cargo receptor activity of LRP2:LDLRAP1 [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:350121] Jassal, Bijay, 2008-05-14
edited	[InstanceEdit:352314] Jassal, B, 2008-06-02 10:50:11
input	[Complex:350115] CUBN:GC:25(OH)D [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:350114] Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties [LiteratureReference:350124] Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin [LiteratureReference:8963845] An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3 [LiteratureReference:8963846] Role of megalin and cubilin in the metabolism of vitamin D(3)
modified	[InstanceEdit:350196] Jassal, B, 2008-05-14 09:44:00 [InstanceEdit:352338] Jassal, B, 2008-06-02 16:22:02 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:6807513] D'Eustachio, Peter, 2015-11-02 [InstanceEdit:8963878] Jassal, Bijay, 2017-02-13 [InstanceEdit:9028764] Jassal, Bijay, 2017-11-09 [InstanceEdit:9639412] D'Eustachio, Peter, 2019-03-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9959973] D'Eustachio, Peter, 2025-07-03
name	LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D
output	[Complex:350092] CUBN:GC:25(OH)D [cytosol] [Homo sapiens]
precedingEvent	[Reaction:350186] CUBN binds GC:25(OH)D [Homo sapiens] [Reaction:209944] 25(OH)D binds GC [Homo sapiens]
releaseDate	2008-06-30
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360182] R-HSA-350168.7
summation	[Summation:350154] Megalin (LRP2, glycoprotein 330) is a member of the low dens...
(hasEvent)	[Pathway:196791] Vitamin D (calciferol) metabolism [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:209760] Endocytic translocation of CUBN:GC:25(OH)D to lysosomal lumen [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775106] Update Tracker - [BlackBoxEvent:350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - v80:[modifyText] [_UpdateTracker:9780271] Update Tracker - [BlackBoxEvent:350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - v63:[modifyText] [_UpdateTracker:9781991] Update Tracker - [BlackBoxEvent:350168] LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D - v60:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by LRP2-mediated uptake of extracellular CUBN:GC:25(OH)D (350168)