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Details on Person PCAF [nucleoplasm]

Class:Id	CandidateSet:350078
_displayName	PCAF [nucleoplasm]
_timestamp	2013-01-30 15:18:26
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:350077] Caudy, M, 2008-05-14 09:28:31
hasCandidate	[EntityWithAccessionedSequence:3006516] KAT2A [nucleoplasm] [Homo sapiens]
hasMember	[EntityWithAccessionedSequence:352430] KAT2B [nucleoplasm] [Homo sapiens]
modified	[InstanceEdit:352435] Caudy, M, 2008-06-02 23:39:56 [InstanceEdit:352464] Caudy, M, 2008-06-03 00:23:14 [InstanceEdit:3006517] Jupe, S, 2013-01-30
name	PCAF
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:378413] R-HSA-350078.1
(hasComponent)	[Complex:212451] CSL NICD coactivator complex [nucleoplasm] [Homo sapiens] [Complex:1604462] NOTCH1 Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:2064911] xNOTCH1 Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:2065276] mNICD1 Chimeric Enhancer Complex [nucleoplasm] [Homo sapiens] [Complex:2220989] NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm] [Homo sapiens] [Complex:9977595] NOTCH1,2 Coactivator Complex [nucleoplasm] [Homo sapiens]
(input)	[Reaction:212356] Formation of CSL-NICD coactivator complex [Homo sapiens] [Reaction:1912394] NICD1 in complex with RBPJ (CSL) recruits MAML [Homo sapiens] [Reaction:2220964] NICD1 PEST domain mutants in complex with RBPJ (CSL) bind MAML [Homo sapiens] [Reaction:9976117] STAT6, NFATC2 (NFAT1), and NICD1,2 bind the GATA3 gene and cause displacement of repressor complexes (PRC1, RBPJ:NCOR) by activator complexes (MLL1, RBPJ:NICD1,2) [Homo sapiens] [Reaction:9979250] NICD1 and coactivators displace corepressors from RBPJ:SNW1:HES1 gene [Homo sapiens]
(output)	[Reaction:1912391] NICD1 is phosphorylated by CDK8 [Homo sapiens] [Reaction:2065178] CDK8 phosphorylates xNICD1 [Homo sapiens] [Reaction:2220971] CDK8 phosphorylates NICD1 PEST domain mutants [Homo sapiens]
(physicalEntity)	[CatalystActivity:109690] acetyltransferase activity of PCAF [nucleoplasm]
(updatedInstance)	[_UpdateTracker:9877413] Update Tracker - [CandidateSet:350078] PCAF [nucleoplasm] - v44:[add_removeHasCandidate]
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No pathways have been reviewed or authored by PCAF [nucleoplasm] (350078)