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Query author contributions in Reactome

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Details on Person An extracellular spherical HDL particle binds to the plasma ...

Class:IdSummation:349643
_displayNameAn extracellular spherical HDL particle binds to the plasma ...
_timestamp2008-05-12 16:04:14
created[InstanceEdit:349639] D'Eustachio, P, 2008-05-12 16:04:08
literatureReference[LiteratureReference:349635] The cellular biology of scavenger receptor class B type I
[LiteratureReference:349648] The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues
textAn extracellular spherical HDL particle binds to the plasma membrance-associated SR-BI receptor with high affinity (Murao et al. 1997). In the body SR-BI receptors are abundant on the surfaces of steroidogenic cells in the adrenal glands and gonads, and on hepatocytes. SR-BI thus appears to play a central role in cholesterol uptake for steroid hormone synthesis and for bile acid synthesis and cholesterol excretion (Rigotti et al. 2003; Silver and Tall 2001).
(summation)[Reaction:349637] spherical HDL and SR-BI receptor form a complex at the cell surface [Homo sapiens]
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