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Details on Person Phosphorylation of MDM4 by ATM

Class:Id	Reaction:349455
_displayName	Phosphorylation of MDM4 by ATM
_doRelease	TRUE
_timestamp	2022-02-22 12:56:47
authored	[InstanceEdit:264438] Matthews, L, 2008-03-31 10:45:58
catalystActivity	[CatalystActivity:5693530] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:349466] Matthews, L, 2008-05-07 22:49:21
edited	[InstanceEdit:351820] Matthews, L, 2008-05-12 14:39:01
input	[SimpleEntity:29358] ATP [nucleoplasm] [Complex:6804932] p-S166,S188-MDM2:MDM4 [nucleoplasm] [Homo sapiens]
literatureReference	[LiteratureReference:349458] Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage [LiteratureReference:349453] ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
modified	[InstanceEdit:349479] Matthews, L, 2008-05-07 22:55:23 [InstanceEdit:352490] Matthews, L, 2008-06-03 01:07:17 [InstanceEdit:354042] Matthews, L, 2008-06-14 07:36:31 [InstanceEdit:354043] Matthews, L, 2008-06-14 07:41:39 [InstanceEdit:354051] Matthews, L, 2008-06-16 15:39:05 [InstanceEdit:1168654] Matthews, L, 2011-01-05 [InstanceEdit:6792749] Orlic-Milacic, Marija, 2015-08-26 [InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:6804943] Orlic-Milacic, Marija, 2015-10-15 [InstanceEdit:8856346] Orlic-Milacic, Marija, 2016-02-09 [InstanceEdit:8856587] Orlic-Milacic, Marija, 2016-02-10 [InstanceEdit:8979260] Orlic-Milacic, Marija, 2017-02-23 [InstanceEdit:9766481] Orlic-Milacic, Marija, 2022-02-22 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of MDM4 by ATM
negativePrecedingEvent	[NegativePrecedingEvent:9766476] Futile Cycle: MDM2 ubiquitinates TP53
output	[SimpleEntity:113582] ADP [nucleoplasm] [Complex:6804939] p-S166,S188-MDM2:p-S403-MDM4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:6804741] MDM2 forms homo- or heterodimers [Homo sapiens] [Reaction:6793666] MDM2 translocates to the nucleus [Homo sapiens]
releaseDate	2016-03-23
releaseStatus	NEW
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8861206] R-HSA-349455.4
summation	[Summation:349432] Human MDM4 (MDMX) is phosphorylated on serine residue S403 b...
(hasEvent)	[Pathway:69541] Stabilization of p53 [Homo sapiens] [Pathway:6804757] Regulation of TP53 Degradation [Homo sapiens]
(precedingEvent)	[Reaction:349426] Phosphorylation of MDM4 by CHEK2 [Homo sapiens]
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